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Neurocognitive Function and Neuroimaging Markers in Virologically Suppressed HIV-positive Patients Randomized to Ritonavir-boosted Protease Inhibitor Monotherapy or Standard Combination ART: A Cross-sectional Substudy From the PIVOT Trial.

Author: , Arenas-PintoAlejandro, CairnsJanet, ChenFabian, ClarkeAmanda, GodiClaudia, GolayXavier, HaddowLewis, JohnsonMargaret, JägerHans Rolf, PatonNicholas I, SolankyBhavana S, StöhrWolfgang, ThustSteffi, TrombinRita, WinstonAlan

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the neurocognitive function and brain imaging markers of patients on ritonavir-boosted protease inhibitor (PI) monotherapy versus standard antiretroviral therapy (ART). There was no difference in neurocognitive impairment between the two groups. However, symptomatic neurocognitive impairment was associated with higher global cortical atrophy scores.
Paper Details　
Original Abstract of the Article :
BACKGROUND: To determine whether treatment with ritonavir-boosted protease inhibitor (PI) monotherapy is associated with detrimental effects on neurocognitive function or brain imaging markers compared to standard antiretroviral therapy (ART). METHODS: Neuropsychological assessment and brain magnet...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928386/

データ提供：米国国立医学図書館（NLM）

Neurocognitive Function: A Balancing Act in HIV-Positive Patients

This research, like a meticulous caravan navigating a vast desert, explores the impact of different HIV treatment regimens on neurocognitive function. The researchers, equipped with cutting-edge neuropsychological assessments and brain imaging techniques, meticulously compared patients receiving ritonavir-boosted protease inhibitor monotherapy (PI-mono) with those on standard antiretroviral therapy (OT). They sought to determine whether PI-mono posed any detrimental effects on the brain.

A Tale of Two Treatment Regimens: No Significant Differences

The study revealed no significant differences in neurocognitive function or brain imaging markers between the two treatment groups. It's like discovering a hidden oasis in the desert, where both pathways lead to similar outcomes. This finding is reassuring for patients and clinicians alike, suggesting that PI-mono may not compromise brain health in the long run.

HIV Treatment: A Balancing Act

This research, like a wise traveler's compass, guides us towards a better understanding of HIV treatment strategies. It emphasizes the importance of careful monitoring and individualized care for HIV-positive patients. While PI-mono appears to be safe for the brain, it's crucial to continue research and explore optimal treatment options for this complex disease.

Dr. Camel's Conclusion

This study, like a shimmering mirage in the vast desert of HIV research, provides valuable insights into the neurocognitive effects of different treatment regimens. It suggests that PI-mono does not increase the risk of neurocognitive impairment in stable HIV-positive patients. As we continue our quest for effective and safe treatments, let's remember that knowledge is our compass, guiding us towards a healthier future for all.

Date :
  1. Date Completed 2017-12-11
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

27143662

DOI: Digital Object Identifier

PMC4928386

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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