Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-naïve vs. antipsychotic-exposed rats.

Author: BuonaguroElisabetta F, IasevoliFelice, LatteGianmarco, MarmoFederica, TomasettiCarmine, de BartolomeisAndrea

Paper Details 
Original Abstract of the Article :
The postsynaptic density (PSD) has been regarded as a functional switchboard at the crossroads of a dopamine-glutamate interaction, and it is putatively involved in the pathophysiology of psychosis. Indeed, it has been demonstrated that antipsychotics may modulate several PSD transcripts, such as PS...See full text at original site
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引用元:
https://doi.org/10.1016/j.pnpbp.2016.04.015

データ提供:米国国立医学図書館(NLM)

Switching Antipsychotics: A Journey Through Synaptic Landscapes

The brain is a complex landscape, like a vast desert with intricate pathways and hidden oases. [Antipsychotic medications] are used to navigate this complex terrain, but their effects can vary depending on the individual and the specific medication used.

This study explored the effects of switching between different [antipsychotics] on the [postsynaptic density (PSD)], a crucial structure involved in communication between nerve cells.

The researchers found that switching [antipsychotics] can have different effects on the expression of genes in the [PSD], depending on whether the individual has been previously exposed to antipsychotics.

The Impact of Switching Antipsychotics on Synaptic Function

The study suggests that switching [antipsychotics] may have significant implications for the brain's ability to adapt and learn, much like changing routes across a desert can lead to new discoveries.

Implications for Antipsychotic Treatment

This research provides valuable insights into the effects of switching [antipsychotics] and the potential impact on brain function. By understanding these effects, doctors can make more informed decisions about treatment strategies for patients with [psychosis], ultimately leading to better outcomes.

Dr.Camel's Conclusion

The desert of the brain is vast and complex, with hidden pathways and intricate connections. This research sheds light on the effects of switching antipsychotics on this complex landscape, highlighting the importance of considering an individual's history and the potential impact on brain function. As a researcher, I am fascinated by the intricate mechanisms of the brain and the constant quest to unravel its mysteries.

Date :
  1. Date Completed 2017-04-12
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27177972

DOI: Digital Object Identifier

10.1016/j.pnpbp.2016.04.015

Related Literature

SNS
PICO Info
in preparation
Languages

English

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