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Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data.
Author: ConnorKathryn M, HerringW Joseph, LinesChristopher, MaJunshui, MichelsonDavid, SnyderEllen, SvetnikVladimir
Original Abstract of the Article :
BACKGROUND: The orexin receptor antagonist, suvorexant, is approved for treating insomnia at a maximum dose of 20 mg. We evaluated its effects on sleep architecture. METHODS: The analyses included pooled polysomnography data from two similar randomized, double-blind, placebo-controlled, 3-month tri...See full text at original site
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引用元:
https://doi.org/10.1016/j.sleep.2015.10.007
データ提供:米国国立医学図書館(NLM)
Suvorexant for Insomnia: A Deep Dive into Sleep Architecture
Sleep is a fundamental aspect of human health, and insomnia can have a profound impact on our well-being. This research dives into the intricate world of sleep architecture, examining the effects of suvorexant, an orexin receptor antagonist, on sleep patterns. This study is like a meticulous examination of a desert oasis, meticulously analyzing its components and their interactions. The researchers conducted a pooled analysis of data from two large clinical trials, examining the effects of suvorexant on sleep stages and brain wave activity. This comprehensive approach is akin to a desert expedition, covering vast terrain and uncovering hidden details. The study found that suvorexant increased the overall time spent in all sleep stages, suggesting a potential benefit for individuals struggling with insomnia.Suvorexant: A Potential Sleep Aid
The study’s findings provide evidence that suvorexant could be an effective treatment option for insomnia, helping individuals achieve deeper and more restful sleep. However, the study also found that the effects of suvorexant on specific sleep stages diminished over time. This is like finding a spring that initially provides ample water but gradually dwindles as the desert landscape changes. The study highlights the importance of ongoing monitoring and evaluation to ensure the continued effectiveness of suvorexant in the long term.Understanding Sleep and Insomnia
This research provides valuable insights into the complex mechanisms of sleep and the potential benefits and challenges of medication-based interventions for insomnia. The findings emphasize the importance of individualized care, considering each patient’s unique sleep patterns and potential for side effects. This is like choosing the best campsite in the desert, carefully considering factors like water availability, shelter, and safety. The study also underscores the need for further research to fully understand the long-term effects of suvorexant on sleep architecture and overall health.Dr.Camel’s Conclusion
This research provides a valuable contribution to our understanding of insomnia and the potential role of suvorexant in its treatment. Like a seasoned traveler navigating the desert of sleep, the researchers have shed light on the complexities of sleep architecture and the challenges of achieving restful sleep. This research provides a roadmap for future research and clinical practice, guiding us towards a deeper understanding of sleep and more effective treatments for insomnia.Date :
- Date Completed 2017-11-16
- Date Revised 2022-04-09
Further Info :
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PICO Info
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Languages
English
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