Comparison of different methods to study effects of silver nanoparticles on the pro- and antioxidant status of human keratinocytes and fibroblasts.

Author: AhlbergSebastian, EppleMatthias, GereckeChristian, HöppeDavid, KleuserBurkhard, LademannJürgen, LozaKateryna, MeinkeMartina C, RancanFiorenza, VogtAnnika

Paper Details 
Original Abstract of the Article :
In times of antibiotic-resistant bacteria new strategies to avoid the septic-inducing threat of dangerous microorganisms are needed. Silver ions (Ag<sup>+</sup>) in the forms of silver nitrate or silver sulfadiazine have been used as antimicrobial agents for years. A step further was the development...See full text at original site
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引用元:
https://doi.org/10.1016/j.ymeth.2016.05.015

データ提供:米国国立医学図書館(NLM)

Silver Nanoparticles: A Double-Edged Sword

The world of nanotechnology is constantly evolving, with new materials and applications emerging at an astonishing rate. This research, like a pioneering explorer venturing into uncharted territory, delves into the intriguing world of silver nanoparticles (AgNP) and their potential use as antimicrobial agents. This study, with its meticulous methodology, seeks to understand the complex effects of AgNP on human cells, exploring both their potential benefits and risks.

A Balancing Act of Benefits and Risks

The study found that AgNP, like a double-edged sword in the desert, can exhibit both antimicrobial and cytotoxic effects. It's like discovering a precious oasis that, while offering life-sustaining water, also harbors a venomous snake. The study found that AgNP with high concentrations of released silver ions can induce oxidative stress and deplete cells of their natural antioxidants, ultimately leading to cell death. However, AgNP prepared and stored under argon, like a carefully protected oasis, did not exhibit significant adverse effects.

Navigating the Desert of Nanotechnology

This research underscores the importance of careful consideration of AgNP formulations and their potential for toxicity. It's like recognizing that even the most promising desert resource requires careful management to avoid unintended consequences.

Dr.Camel's Conclusion

This research, like a desert oasis both beautiful and dangerous, highlights the complex nature of nanotechnology. It underscores the need for careful research and development to ensure the safe and effective use of these promising new materials.

Date :
  1. Date Completed 2018-01-23
  2. Date Revised 2018-05-21
Further Info :

Pubmed ID

27215495

DOI: Digital Object Identifier

10.1016/j.ymeth.2016.05.015

SNS
PICO Info
in preparation
Languages

English

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