Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis.

Author: CaoWen-Ming, CuiYunfu, DouJun, JiangZheng, WangHao, WangZhenyu, YuYang, ZhangHong, ZhaoYanling

Paper Details 
Original Abstract of the Article :
Doxorubicin (Dox), one of the most effective chemotherapy drug for cancer treatment, is limited by its severe side effects and chemoresistance. Dox induces DNA damage and leads to significant proteomic changes in the cancer cells, which makes the ubiquitin-proteasome system a potential target to enh...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877646/

データ提供:米国国立医学図書館(NLM)

Next-Generation Proteasome Inhibitor MLN9708 Sensitizes Breast Cancer Cells to Doxorubicin-Induced Apoptosis

Breast cancer, like a thorny desert landscape, poses a formidable challenge for researchers and clinicians. This study, published in [Journal Name], investigates the potential of a next-generation proteasome inhibitor, MLN9708, in combination with a commonly used chemotherapy drug, doxorubicin, to enhance the treatment of breast cancer.

A Promising Combination for Breast Cancer Treatment

The researchers, like intrepid explorers traversing a harsh desert, found that MLN9708, in combination with doxorubicin, significantly enhanced the killing of breast cancer cells. This combination, like a potent antidote for a venomous desert creature, triggered a cascade of events leading to increased cell death, suggesting a potential new therapeutic strategy for breast cancer.

Optimizing Treatment Strategies for Breast Cancer

This research holds promise for improving the effectiveness of breast cancer treatment, potentially reducing the need for aggressive therapies and improving the quality of life for patients. The study's findings, like a well-charted oasis, provide a valuable roadmap for further research and development of more effective and targeted treatments for this challenging disease.

Dr. Camel's Conclusion

This research, like a refreshing spring in the desert, offers a ray of hope for patients battling breast cancer. The study's findings suggest that MLN9708, when combined with doxorubicin, may offer a potent weapon against breast cancer cells, paving the way for more effective and personalized treatment strategies. As we continue to explore the intricate landscape of cancer research, this study serves as a reminder that relentless curiosity and innovative approaches can lead to groundbreaking discoveries that improve the lives of countless individuals.
Date :
  1. Date Completed 2018-05-15
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27217076

DOI: Digital Object Identifier

PMC4877646

Related Literature

SNS
PICO Info
in preparation
Languages

English

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