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Original Abstract of the Article :
Calcimimetics act as positive allosteric modulators of the calcium-sensing receptor (CaSR), thereby decreasing parathyroid hormone (PTH) secretion from the parathyroid glands. On the other hand, negative allosteric modulators of the CaSR with stimulatory effect on PTH secretion are termed calcilytic...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/27230839
データ提供:米国国立医学図書館(NLM)
Calcium-Sensing Receptor: A Molecular Gatekeeper of Calcium Balance
This research explores the fascinating world of the calcium-sensing receptor (CaSR), a molecular gatekeeper that regulates calcium levels in the body. The study focuses on the role of allosteric modulators, molecules that influence the activity of the CaSR, in maintaining calcium homeostasis. The research examines cinacalcet hydrochloride, a calcimimetic drug that acts as a positive allosteric modulator of the CaSR, and its impact on parathyroid hormone (PTH) secretion, a key regulator of calcium levels. The study also explores the potential of calcilytics, negative allosteric modulators of the CaSR, for various medical applications, including osteoporosis, asthma, and pulmonary hypertension.Tuning the Calcium Orchestra: The Power of Allosteric Modulators
The study highlights the importance of carefully tuning the activity of the CaSR to maintain calcium balance, much like a conductor guiding the delicate harmony of an orchestra. The research provides valuable insights into the mechanisms of action of cinacalcet hydrochloride, a drug used to treat hyperparathyroidism, a condition characterized by excessive PTH production. The study also explores the therapeutic potential of calcilytics, offering a new avenue for treating conditions associated with dysregulation of calcium signaling.A Desert Oasis of Calcium Balance: Maintaining Harmony
Think of the body's calcium levels as a delicate balance within a vast desert ecosystem. This research, like a desert well providing essential resources, emphasizes the importance of maintaining calcium homeostasis for overall health and well-being. The study highlights the critical role of the CaSR in regulating calcium levels and explores the potential of allosteric modulators, like cinacalcet hydrochloride, to restore balance and prevent imbalances that can lead to various health problems.Dr. Camel's Conclusion
This research, like a journey through the vast desert of calcium signaling, provides a deeper understanding of the calcium-sensing receptor and its role in maintaining calcium homeostasis. The study highlights the potential of allosteric modulators to effectively manage conditions associated with calcium imbalances, offering a promising avenue for future therapeutic strategies.Date :
- Date Completed 2016-12-13
- Date Revised 2018-12-02
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