PROSPERA: a randomized, controlled trial evaluating rasagiline in progressive supranuclear palsy.

Author: CrispinAlexander, HenslerMira, LorenzlStefan, NueblingGeorg, PaulSabine, ZwergalAndreas

Paper Details 
Original Abstract of the Article :
To date, pharmacological treatment options for progressive supranuclear palsy (PSP), a neurodegenerative tauopathy, are limited. The MAO-B inhibitor rasagiline has shown neuroprotective effects in preclinical models of neurodegeneration. To evaluate the safety, tolerability and therapeutic effect of...See full text at original site
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引用元:
https://doi.org/10.1007/s00415-016-8169-1

データ提供:米国国立医学図書館(NLM)

Rasagiline: A New Hope for Progressive Supranuclear Palsy?

Progressive supranuclear palsy (PSP), a neurodegenerative tauopathy, is a debilitating disease with limited treatment options. This research investigates the potential of rasagiline, a MAO-B inhibitor, as a treatment for PSP, evaluating its safety, tolerability, and therapeutic effects. This study is like venturing into a hidden valley in the desert of PSP research, searching for new and effective treatments for this challenging condition.

Rasagiline Shows Promise in PSP Treatment

The study found that rasagiline was well-tolerated but did not demonstrate a significant effect on overall symptom progression in PSP. This finding is like finding a hidden oasis in the desert, but the water proves to be scarce. It underscores the need for further research to better understand the potential benefits of rasagiline in PSP and explore alternative approaches.

Navigating the Complexities of PSP Treatment

This research highlights the complex challenges of treating PSP and the importance of developing more specific endpoints for future studies. It encourages a focus on personalized medicine, tailoring treatments to the individual needs of patients. Think of it as a journey through the desert of PSP research, where we need to find the best combination of resources to navigate the challenges.

Dr.Camel's Conclusion

This study provides valuable insights into the potential of rasagiline as a treatment for PSP. It emphasizes the need for further research to better understand the complex mechanisms of this disease and develop more effective and personalized treatment strategies.

Date :
  1. Date Completed 2017-04-11
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27230855

DOI: Digital Object Identifier

10.1007/s00415-016-8169-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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