Bexarotene protects against traumatic brain injury in mice partially through apolipoprotein E.

Author: CaoFang, ChengChongjie, HeJunchi, HuangZhijian, JiangLi, LiuHan, SunXiaochuan, TengZhipeng, WuJinchuan, WuYue, ZhangHongrong, ZhongJianjun

Paper Details 
Original Abstract of the Article :
Bexarotene has been proved to have neuroprotective effects in many animal models of neurological diseases. However, its neuroprotection in traumatic brain injury (TBI) is still unknown. This study aims to explore the neuroprotective effects of bexarotene on TBI and its possible mechanism. Controlled...See full text at original site
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引用元:
https://doi.org/10.1016/j.neuroscience.2016.05.033

データ提供:米国国立医学図書館(NLM)

Bexarotene's Protective Effects Against Traumatic Brain Injury

This study delves into the potential of bexarotene, a drug with neuroprotective properties, in treating traumatic brain injury (TBI). The researchers, like intrepid explorers seeking a cure for a devastating condition, used a controlled cortical impact model to simulate TBI in mice. Their findings suggest that bexarotene may offer a promising therapeutic avenue for TBI, with a particular focus on its role in promoting the body's natural healing mechanisms.

Bexarotene's Neuroprotective Potential

This research unveils the potential of bexarotene in mitigating the damaging effects of TBI. The findings, like a restorative oasis in the desert of brain injury, demonstrate that bexarotene significantly improved motor function and spatial memory in mice with TBI. This neuroprotective effect seems to be mediated, at least in part, by the drug's ability to reduce inflammation and cell death around the injury site.

Hope on the Horizon for TBI Treatment

This study offers a glimmer of hope for individuals suffering from TBI. The findings, like a beacon guiding us towards a brighter future, suggest that bexarotene may hold the key to developing more effective treatments for this debilitating condition. Further research is crucial, but this study provides a valuable foundation for exploring the potential of bexarotene in TBI therapy.

Dr.Camel's Conclusion

This study provides promising evidence for the neuroprotective effects of bexarotene in treating traumatic brain injury. The findings, like a shimmering mirage in the desert of brain injury research, suggest that this drug could play a significant role in future TBI treatment strategies. While further research is needed, this study offers a beacon of hope for individuals battling the challenges of TBI.

Date :
  1. Date Completed 2017-11-17
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

27235741

DOI: Digital Object Identifier

10.1016/j.neuroscience.2016.05.033

Related Literature

SNS
PICO Info
in preparation
Languages

English

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