Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency.

Author: DiasioRobert B, SaifMuhammad Wasif

Paper Details 
Original Abstract of the Article :
5-Fluorouracil (5-FU), an analog of uracil, is one of the most commonly used chemotherapeutic agents and like other agents has a narrow therapeutic index limited by toxicity. Compared to previous attempts, uridine triacetate (Vistogard) has shown to increase the potential efficacy of 5-FU by allowin...See full text at original site
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引用元:
https://doi.org/10.1007/s00280-016-3063-1

データ提供:米国国立医学図書館(NLM)

Uridine Triacetate: A Lifeline for Severe 5-Fluorouracil Toxicity

The world of chemotherapy, like a scorching desert, is often marked by harsh side effects. 5-fluorouracil (5-FU), a common chemotherapy drug, can cause severe toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency, a condition that impairs the body's ability to break down the drug. This study delves into the potential of uridine triacetate (Vistogard) as a life-saving antidote for these patients. Uridine triacetate, like a refreshing spring in the desert, has shown promise in rescuing patients from severe 5-FU toxicity, potentially allowing them to receive higher doses of the drug while minimizing harmful side effects.

A Potential Oasis for Patients with DPYD Deficiency

The study highlights the significant potential of uridine triacetate as a treatment for severe 5-FU toxicity in patients with DPYD deficiency. This discovery, like a hidden oasis in the desert, offers a glimmer of hope for these individuals, potentially reducing the severity of side effects and allowing them to continue receiving life-saving treatment. While more research is needed to fully understand the long-term impact of uridine triacetate, it holds immense promise for patients with DPYD deficiency.

A Beacon of Hope in the Desert of Chemotherapy

The study underscores the importance of developing new strategies to mitigate the toxic effects of chemotherapy drugs, like finding a source of water in a dry wasteland. This research, like a beacon of hope, shines a light on the potential of uridine triacetate to improve the lives of patients experiencing severe 5-FU toxicity. It serves as a reminder that even in the harsh landscape of chemotherapy, there is always a search for solutions to alleviate suffering and improve patient outcomes.

Dr.Camel's Conclusion

The potential of uridine triacetate as a treatment for severe 5-FU toxicity in patients with DPYD deficiency, like a refreshing oasis in a desert, is a significant breakthrough in the world of chemotherapy. While further research is crucial, this discovery offers a glimmer of hope for patients struggling with this challenging condition.

Date :
  1. Date Completed 2017-06-06
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

27278667

DOI: Digital Object Identifier

10.1007/s00280-016-3063-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

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