Paper Details

  1. Home
  2. Paper Details

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists.

Author: AffiniAnna, ButiniStefania, KhanfarMohammad A, LutsenkoKiril, NikolicKatarina, StarkHolger

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study discusses the clinical applications of novel multifunctional histamine H3 receptor antagonists, particularly pitolisant (Wakix®). The combination of pharmacological properties in one molecule for improved pharmacological effects and reduced side effects is a promising strategy based on the increasing understanding of complex neurotransmitter regulations. Polypharmacological approaches on histamine H3 receptor antagonists are described, including interactions with G-protein coupled receptors, transporters, enzymes, and NO-signaling mechanisms.
Paper Details　
Original Abstract of the Article :
With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884744/

データ提供：米国国立医学図書館（NLM）

Histamine H3 Receptor Antagonists: A Multifaceted Approach to Therapeutic Development

This article delves into the therapeutic potential of histamine H3 receptor antagonists, highlighting their multifaceted nature and potential for treating a range of conditions. The authors discuss the growing interest in these antagonists, spurred by the recent market approval of pitolisant for narcolepsy. They emphasize the polypharmacological approach to developing these agents, considering their interactions with various G-protein coupled receptors, transporters, enzymes, and NO-signaling pathways. The article explores the potential benefits of targeting multiple pathways with a single molecule, aiming to enhance therapeutic efficacy while minimizing unwanted side effects.

The Desert of Drug Discovery: A Multi-Target Oasis

This article underscores the innovative approach of developing multi-target drugs, specifically histamine H3 receptor antagonists, as a promising strategy in the realm of drug discovery. The authors' exploration of the intricate interactions of these compounds with various biological targets highlights the potential to address multiple conditions simultaneously, potentially leading to more effective and well-tolerated treatments.

Navigating the Desert of Therapeutic Development: A New Path Forward

The journey through the desert of therapeutic development often involves a search for more effective and targeted treatments. This article illuminates the potential of polypharmacology, using multi-target compounds like histamine H3 receptor antagonists, to offer new pathways for achieving therapeutic success.

Dr. Camel's Conclusion

This article showcases the exciting potential of polypharmacology in drug development, specifically with histamine H3 receptor antagonists. The authors' exploration of the intricate interactions of these compounds with various biological targets provides a roadmap for developing more effective and targeted treatments for a range of conditions, offering a refreshing oasis in the desert of therapeutic development.

Date :
  1. Date Completed 2016-06-15
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

27303254

DOI: Digital Object Identifier

PMC4884744

Related Literature

Article Analysis
・Side Effects of pitolisant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.