Paper Details 
Original Abstract of the Article :
The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new treatments for human diseases. Previous studies have reported polyphosphate (PolyP)-mediated vascular inflammatory responses such as disruption of vascular integrity. Da...See full text at original site
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引用元:
https://doi.org/10.1016/j.cbi.2016.07.024

データ提供:米国国立医学図書館(NLM)

Dabrafenib: A New Hope for Polyphosphate-Mediated Vascular Disruption

Inflammation is a complex process, like a desert sandstorm that can wreak havoc on the body. This research investigates the potential of dabrafenib, a drug initially used for melanoma treatment, as a new therapeutic agent to combat vascular inflammatory responses triggered by polyphosphate. The study explores dabrafenib's ability to inhibit the damaging effects of polyphosphate, a substance that can disrupt vascular integrity and contribute to inflammatory conditions. The researchers observed that dabrafenib effectively suppressed polyphosphate-mediated vascular permeability and inflammation in both cell cultures and animal models. This study provides promising insights into the potential of repurposing existing drugs for new therapeutic applications.

Dabrafenib: A Potential New Weapon Against Vascular Inflammation

This study suggests that dabrafenib, a drug already approved for melanoma, could be repurposed as a therapeutic agent to combat polyphosphate-mediated vascular inflammation. The findings demonstrate dabrafenib’s ability to effectively suppress vascular permeability, reduce inflammatory biomarkers, and mitigate the lethal effects of polyphosphate. This study opens up exciting possibilities for exploring new therapeutic applications for existing drugs, potentially leading to more effective treatments for inflammatory conditions.

Dabrafenib: A New Oasis in the Desert of Inflammation

This study is like a camel discovering a hidden oasis in a parched desert, offering a new source of hope for combating vascular inflammation. The repurposing of dabrafenib, a drug initially developed for melanoma, as a potential treatment for polyphosphate-mediated vascular inflammation, is a testament to the power of scientific exploration and the potential for innovation in medicine. This research highlights the importance of investigating new therapeutic applications for existing drugs, potentially leading to more effective and targeted treatments for a wide range of conditions.

Dr.Camel's Conclusion

This research is a reminder that in the vast desert of medicine, new discoveries are constantly emerging. The potential of repurposing existing drugs, like dabrafenib, to treat new conditions, such as polyphosphate-mediated vascular inflammation, is a testament to the ongoing quest for innovative solutions to challenging health problems. It’s a reminder to stay curious, explore new horizons, and embrace the possibilities that lie ahead.

Date :
  1. Date Completed 2017-01-30
  2. Date Revised 2017-01-30
Further Info :

Pubmed ID

27458080

DOI: Digital Object Identifier

10.1016/j.cbi.2016.07.024

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