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Comparative study on the in vitro performance of blister molded and conventional lornoxicam immediate release liquitablets: accelerated stability study and anti-inflammatory and ulcerogenic effects.
Author: BadawiAlia Abd El-Latif, El-SetouhyDoaa Ahmed, GamielAlaa Abdel-Rahman, LabibDina Ahmed, OsmanAfaf Sayed
Original Abstract of the Article :
CONTEXT: Lornoxicam is a potent non-steroidal anti-inflammatory drug (NSAID). It shows limited solubility in the gastric pH, delayed bioavailability and pharmacodynamic effects with aggravated gastric side effects (due to longer residence in the stomach wall). OBJECTIVE: To enhance dissolution of l...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1080/10837450.2016.1221423
データ提供:米国国立医学図書館(NLM)
Unlocking the Potential of Lornoxicam Liquitablets
Lornoxicam is a powerful pain reliever, but its effectiveness can be hampered by its limited solubility. This study explores the use of blister molding, a novel manufacturing technique, to enhance the dissolution and bioavailability of lornoxicam liquitablets. The researchers sought to create a more efficient and effective delivery system for this potent drug, akin to a camel carrying a precious cargo across the desert, ensuring it reaches its destination with ease.
The study compared blister-molded lornoxicam liquitablets to conventional liquitablets, finding that the blister molding technique significantly enhanced the dissolution of lornoxicam. The blister-molded liquitablets showed significantly improved anti-inflammatory activity and reduced gastric ulcerative effects compared to pure lornoxicam and commercial formulations. This research suggests that blister molding may provide a more effective and safer way to deliver lornoxicam, potentially improving patient outcomes.
Blister Molding: A Game-Changer for Lornoxicam
This study highlights the potential of blister molding as a novel manufacturing technique to improve the dissolution and bioavailability of lornoxicam. The researchers demonstrated that this technique can significantly enhance the effectiveness and safety of lornoxicam liquitablets. This innovation may lead to a new era of more effective and safe pain relief for patients.
A More Efficient Delivery System
This research suggests that blister molding could provide a more efficient and effective delivery system for lornoxicam, potentially improving patient outcomes. The researchers emphasize the importance of exploring innovative manufacturing techniques to enhance drug delivery and optimize therapeutic effects.
Dr.Camel's Conclusion
The desert of pain relief can be a harsh landscape, but researchers are constantly seeking innovative ways to alleviate suffering. This study explores the potential of blister molding to create a more effective and safer delivery system for lornoxicam, offering a potential solution for patients seeking relief from pain.
Date :
- Date Completed 2017-03-15
- Date Revised 2017-03-15
Further Info :
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