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(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.

Author: ChoiKi Hwan, ChungMyeon Woo, LeeHwa Jeong, ParkJung Hyun, UmSo Young

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the use of (1)H-nuclear magnetic resonance ((1)H NMR) spectroscopy to identify biomarkers in rat urine that could be associated with gastrointestinal (GI) damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs). The study found that certain endogenous metabolites in urine were correlated with the severity of GI damage caused by NSAIDs. These findings suggest that (1)H NMR spectroscopy could be a useful tool for predicting the risk of GI damage during drug development.
Paper Details　
Original Abstract of the Article :
Nonsteroidal anti-inflammatory drugs (NSAIDs), which are globally prescribed, exhibit mainly anti-inflammatory and analgesic effects but also can cause adverse effects including gastrointestinal erosions, ulceration, bleeding, and perforation. The purpose of this study was to investigate surrogate b...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2016.07.045

データ提供：米国国立医学図書館（NLM）

The Hidden Language of Urine: Unmasking NSAID-Induced Side Effects

This research takes us on an exciting journey into the world of [nonsteroidal anti-inflammatory drugs (NSAIDs)] and their potential side effects. It's like deciphering ancient hieroglyphics, using [NMR spectroscopy] to uncover the hidden messages within urine.

The Telltale Signs: Metabolomics in Action

The researchers used [NMR spectroscopy] to analyze urine samples from rats treated with various NSAIDs. They discovered that NSAIDs can cause [gastrointestinal damage] in rats, and this damage is reflected in the metabolic profile of their urine. The study identified specific metabolites, such as [citrate, allantoin, 2-oxoglutarate, acetate, benzoate, glycine, and trimethylamine N-oxide], as potential biomarkers for NSAID-induced gastrointestinal damage.

A Window into the Future of Drug Development

This research opens up exciting possibilities for the early detection of adverse effects in drug development. By analyzing the metabolic profile of urine, researchers can potentially identify individuals at risk of developing NSAID-induced gastrointestinal damage. This could help to minimize the risk of side effects and ensure the safety of new drugs.

Health Implications and Everyday Life

This research underscores the importance of understanding the potential side effects of NSAIDs. It's crucial to consult with your healthcare provider about any concerns you may have regarding NSAIDs and to use them cautiously as directed. While NSAIDs can be effective for pain relief, they should be used with awareness of potential side effects. Remember, even the most effective medicine can have unintended consequences.

Dr.Camel's Conclusion

This research highlights the power of metabolomics in identifying potential drug-induced side effects. It's a testament to the ingenuity of researchers who are constantly striving to improve the safety and efficacy of medications.
Date :
  1. Date Completed 2017-05-03
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27497650

DOI: Digital Object Identifier

10.1016/j.jpba.2016.07.045

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