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Comparative Review of Approved Melatonin Agonists for the Treatment of Circadian Rhythm Sleep-Wake Disorders.

Author: DressmanMarlene A, McLinDewey E, NeubauerDavid N, WilliamsWilbur P Trey

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of melatonin receptor agonists for the treatment of circadian rhythm sleep-wake disorders (CRSWDs). While only tasimelteon is currently approved for the treatment of non-24-hour sleep-wake disorder, other melatonin receptor agonists like agomelatine, prolonged-release melatonin, and ramelteon are being investigated for their potential use in treating other CRSWDs. This review summarizes the pharmacologic properties of these agonists and their efficacy in treating CRSWDs, emphasizing the need for further research to determine their full therapeutic potential.
Paper Details　
Original Abstract of the Article :
Circadian rhythm sleep-wake disorders (CRSWDs) are characterized by persistent or recurrent patterns of sleep disturbance related primarily to alterations of the circadian rhythm system or the misalignment between the endogenous circadian rhythm and exogenous factors that affect the timing or durati...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108473/

データ提供：米国国立医学図書館（NLM）

Melatonin Agonists: A Potential Solution for Circadian Rhythm Sleep-Wake Disorders

This research delves into the world of sleep disorders, focusing on circadian rhythm sleep-wake disorders (CRSWDs). It examines the potential of melatonin agonists, medications that mimic the effects of melatonin, as a treatment for these challenging conditions. The study explores the different pharmacologic properties of various melatonin agonists and their potential applications in managing CRSWDs. It's like finding the right rhythm for a desert caravan: we need to adjust our pace and timing to navigate the changing environment and reach our destination.

Melatonin Agonists: A Promising Therapeutic Option

The study highlights the potential benefits of melatonin agonists in treating CRSWDs. It suggests that these medications may help regulate the body's internal clock and improve sleep patterns. While more research is needed to fully understand their efficacy, melatonin agonists offer a promising avenue for managing these challenging conditions. It's like finding a steady compass in the desert: melatonin agonists provide a guiding force for restoring balance and harmony to our internal rhythms.

Improving Sleep Quality: A Foundation for Well-Being

The study emphasizes the importance of addressing sleep disorders, including CRSWDs, to improve overall well-being. Effective management of these conditions can contribute to better sleep quality, increased energy levels, and improved cognitive function. It's like finding a refreshing oasis in the desert: good sleep provides a respite from the challenges of life, restoring our energy and allowing us to thrive.

Dr.Camel's Conclusion

This research highlights the potential benefits of melatonin agonists in treating circadian rhythm sleep-wake disorders. While more research is needed, these medications offer a promising avenue for improving sleep quality and overall well-being for those struggling with these challenging conditions. It's like finding the right rhythm for a desert caravan: melatonin agonists provide a valuable tool for navigating the complexities of sleep and finding the path to a more restful and fulfilling life.

Date :
  1. Date Completed 2017-09-19
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

27500861

DOI: Digital Object Identifier

PMC5108473

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・Effects of tasimelteon
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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