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Pharmacokinetic Effects of Cinnamic Acid, Amygdalin, Glycyrrhizic Acid and Liquiritin on Ephedra Alkaloids in Rats.

Author: ChenJianzhen, ChenYu-Lin, HeYu, TangYinghong, ZhengMengkai

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ephedra alkaloids, such as ephedrine, pseudoephedrine, and methylephedrine, are sympathomimetic compounds known for their toxicities. However, Ephedra preparations have been used for centuries. This study investigated the possible detoxification mechanism of Ephedra alkaloids by examining the pharmacokinetic effects of four compounds found in Ephedra decoction on Ephedra alkaloids in rats.
Paper Details　
Original Abstract of the Article :
Ephedra alkaloids, including ephedrine (EP), pseudoephedrine (PEP) and methylephedrine (MEP), are sympathomimetic compounds with known toxicities but many Ephedra (Ephedrae herba) preparations, such as Ephedra decoction, have been clinically applied for centuries. In order to explore the possible de...See full text at original site
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引用元：
https://doi.org/10.1007/s13318-016-0368-8

データ提供：米国国立医学図書館（NLM）

Ephedra Alkaloids: A Balancing Act Between Benefits and Risks

This research investigates the pharmacokinetic effects of four compounds found in Ephedra decoction (cinnamic acid, amygdalin, glycyrrhizic acid, and liquiritin) on Ephedra alkaloids in rats. The study aims to explore potential detoxification mechanisms for Ephedra alkaloids, which are known to have sympathomimetic properties and associated toxicities.

Unlocking the Potential of Ephedra Decoction

While Ephedra alkaloids have known risks, Ephedra preparations have been used for centuries in traditional medicine. This study explores the possibility of using other components in Ephedra decoction to mitigate the toxicity of Ephedra alkaloids. The research examines the pharmacokinetic interactions of these compounds with Ephedra alkaloids, providing valuable insights into potential detoxification mechanisms.

Navigating the Complexities of Herbal Remedies

The study reminds us that herbal remedies, while often viewed as natural and safe, can have complex interactions with other compounds. It highlights the need for careful research and understanding of these interactions to ensure the safe and effective use of herbal products.

Dr.Camel's Conclusion

This research delves into the fascinating world of Ephedra alkaloids, exploring their potential benefits and risks. The study suggests that other compounds in Ephedra decoction may play a role in mitigating the toxicity of Ephedra alkaloids, offering potential for safer and more effective utilization of this traditional medicinal herb. However, further research is needed to confirm these findings and to fully understand the complex interactions involved.

Date :
  1. Date Completed 2018-02-26
  2. Date Revised 2021-02-24
Further Info :

Pubmed ID

27514823

DOI: Digital Object Identifier

10.1007/s13318-016-0368-8

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in preparation
Languages

English

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