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Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Author: ChintalapatiChakravarthi, GeigerDietmar, GorboulevValentin, GrollJürgen, KellerThorsten, KoepsellHermann, MuellerThomas D, SchäferNadine, Veyhl-WichmannMaike, ZilkowskiIlona
Original Abstract of the Article :
Na<sup>+</sup>-d-glucose cotransporter 1 (SGLT1) is rate-limiting for glucose absorption in the small intestine. Shortly after intake of glucose-rich food, SGLT1 abundance in the luminal membrane of the small intestine is increased. This upregulation occurs via glucose-induced acceleration of the re...See full text at original site
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引用元：
https://doi.org/10.1124/mol.116.104521
データ提供：米国国立医学図書館（NLM）
Protein RS1: A Gatekeeper of Glucose Transport
Glucose homeostasis, the delicate balancing act of maintaining stable blood sugar levels, is crucial for optimal health. This study, my fellow researchers, delves into the intricate regulation of glucose transport, focusing on the role of protein RS1 (RSC1A1) in controlling the exocytotic pathway of glucose transporter SGLT1. The researchers investigated the interaction between RS1 and ornithine decarboxylase 1 (ODC1), a key enzyme in polyamine synthesis. Their findings reveal that RS1-Reg, a domain of RS1, binds to ODC1, inhibiting its enzymatic activity and ultimately influencing the release of SGLT1-containing vesicles from the trans-Golgi network. This intricate interplay suggests a potential role for ODC1 in regulating glucose homeostasis, opening new avenues for understanding and potentially manipulating glucose transport.
A New Key to Glucose Homeostasis: Protein RS1
This study uncovers the intricate regulation of glucose transport, highlighting the role of protein RS1 in controlling the exocytotic pathway of glucose transporter SGLT1. The findings suggest a potential role for ODC1 in regulating glucose homeostasis, opening new avenues for understanding and potentially manipulating glucose transport.
Navigating the Desert of Glucose Homeostasis: A Balanced Journey
The desert of glucose homeostasis is a delicate ecosystem that requires careful management. As Dr. Camel, I’ve learned that navigating this arid landscape requires a balanced approach to ensure optimal health and prevent the dangers of dehydration.
Dr.Camel's Conclusion
This research unravels the intricate regulation of glucose transport, highlighting the role of protein RS1 in controlling the exocytotic pathway of glucose transporter SGLT1. The findings suggest a potential role for ODC1 in regulating glucose homeostasis, offering a new perspective on this crucial aspect of metabolic health.
Date :
- Date Completed 2017-05-09
- Date Revised 2017-05-09
Further Info :
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