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Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor.

Author: ButlerTrent, HuaSusan, IlicicMarina, PaulJonathan W, RobertsonSarah, SmithRoger, TolosaJorge M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Treating obstetric complications like preterm labor and postpartum hemorrhage is challenging due to the systemic toxicity of therapeutic agents. This study explores the use of ligand-targeted liposomes as a novel strategy for targeted drug delivery to uterine myocytes, aiming to improve efficacy and minimize side effects.
Paper Details　
Original Abstract of the Article :
The ability to provide safe and effective pharmacotherapy during obstetric complications, such as preterm labor or postpartum hemorrhage, is hampered by the systemic toxicity of therapeutic agents leading to adverse side effects in the mother and fetus. Development of novel strategies to target toco...See full text at original site
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引用元：
https://doi.org/10.1016/j.ajog.2016.08.027

データ提供：米国国立医学図書館（NLM）

Targeted Drug Delivery to the Uterus: A New Oasis in the Desert of Obstetric Complications

The desert of obstetric complications can be a dangerous and challenging place, filled with unexpected sandstorms and treacherous terrain. This study explores a new approach to targeted drug delivery to the uterus, a strategy that could offer a safer and more effective way to treat obstetric complications.

The researchers are investigating the potential of immunoliposomes targeted to the oxytocin receptor for delivering drugs to the human and mouse uterus. This approach could offer a way to target tocolytic and uterotonic agents specifically to uterine myocytes, minimizing systemic toxicity and adverse side effects. It's like using a camel caravan to deliver supplies directly to a remote oasis, avoiding the dangers of a long and perilous journey.

A More Precise and Targeted Approach

This study offers a promising new approach to drug delivery for obstetric complications. The use of immunoliposomes could lead to more precise and targeted drug delivery, improving therapeutic efficacy while minimizing the risk of side effects. It's like using a GPS to navigate through a desert - it helps you reach your destination safely and efficiently.

Hope for a Safer and More Effective Treatment

This research offers hope for a safer and more effective treatment for obstetric complications. By targeting drugs specifically to uterine myocytes, this approach could reduce the risk of adverse effects on the mother and fetus. It's like finding a hidden oasis in the desert - it offers a safe haven from the harsh realities of the surrounding landscape.

Dr.Camel's Conclusion

This study offers exciting possibilities for the treatment of obstetric complications. The development of immunoliposomes targeted to the oxytocin receptor could revolutionize drug delivery to the uterus, leading to safer and more effective treatments for mothers and their babies.

Date :
  1. Date Completed 2017-06-07
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

27567564

DOI: Digital Object Identifier

10.1016/j.ajog.2016.08.027

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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