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Ex vivo study of human visceral nociceptors.

Author: AhmedShafi, AzizQasim, BlackshawL Ashley, BoundoukiGeorge, BroadJohn, BulmerDavid C, ChanChristopher, Cibert-GotonVincent, HockleyJames R F, KnowlesCharles H, KungVictor, McGuireCian, PeirisMadusha, ReedDavid, SangerGareth J, ThahaMohamed A

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Two distinct populations of human visceral afferent fibers were identified, serosal and muscular, and their sensitivities to different stimuli were investigated. Serosal afferents were found to be more sensitive to bradykinin and ATP, consistent with a role as polymodal nociceptors, while muscular afferents were largely insensitive.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The development of effective visceral analgesics free of deleterious gut-specific side effects is a priority. We aimed to develop a reproducible methodology to study visceral nociception in human tissue that could aid future target identification and drug evaluation. DESIGN: Electrophysi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754853/

データ提供：米国国立医学図書館（NLM）

Unveiling the Secrets of Visceral Pain: A Journey into Human Tissue

The quest for effective visceral analgesics, drugs that relieve pain in internal organs, presents a significant challenge. This research delves into the intricate world of human visceral nociceptors, the nerve endings that detect pain, using an innovative ex vivo approach. The study aims to develop a reliable methodology for studying visceral nociception in human tissue, paving the way for the development of more targeted and effective analgesics.

A Deeper Dive into Visceral Pain: Distinct Populations and Their Responses

The study identifies two distinct populations of visceral afferent fibers: serosal and muscular. The serosal units, potentially responsible for transmitting pain signals, exhibit sensitivity to key algesic mediators, bradykinin and ATP, while the muscular units are largely unresponsive. The research also demonstrates the ability of tegaserod, a drug used to treat irritable bowel syndrome, to attenuate the sensitivity of serosal nociceptors.

Targeting Visceral Pain: A New Frontier in Pain Management

This innovative research paves the way for a deeper understanding of visceral pain mechanisms in humans. It offers a promising platform technology for the identification of new targets for drug development, potentially leading to the development of more effective analgesics with fewer side effects.

Dr. Camel's Conclusion

This study represents a groundbreaking advancement in our understanding of visceral pain. By providing a reliable method for studying human visceral nociceptors, it opens doors for the development of more targeted and effective pain relief solutions. This research is a testament to the power of innovation in addressing complex medical challenges.

Date :
  1. Date Completed 2017-12-18
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

27654583

DOI: Digital Object Identifier

PMC5754853

Related Literature

Article Analysis
・Side Effects of tegaserod・Effects of tegaserod
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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