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Treatment of plaque psoriasis with an ointment formulation of the Janus kinase inhibitor, tofacitinib: a Phase 2b randomized clinical trial.

Author: BissonnetteRobert, DraelosZoe, FeldmanSteven R, GooderhamMelinda, IversenLars, MamoloCarla, PappKim A, PortsWilliam C, PurohitVivek, SoungJennifer, WangCunshan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tofacitinib ointment was found to be more effective than vehicle in treating mild to moderate plaque psoriasis at week 8.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Most psoriasis patients have mild to moderate disease, commonly treated topically. Current topical agents have limited efficacy and undesirable side effects associated with long-term use. Tofacitinib is a small molecule Janus kinase inhibitor investigated for the topical treatment of pso...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048458/

データ提供：米国国立医学図書館（NLM）

Tofacitinib Ointment: A New Path in the Desert of Psoriasis

Psoriasis, a chronic skin condition, can be incredibly frustrating, like a relentless desert sandstorm that leaves your skin dry, itchy, and inflamed. This research, published in the field of dermatology, explores the potential of a topical formulation of tofacitinib, a Janus kinase inhibitor, for treating plaque psoriasis. The study investigated the efficacy and safety of tofacitinib ointment in adults with mild to moderate plaque psoriasis. The results showed that tofacitinib ointment demonstrated greater efficacy than vehicle at Week 8, with significant improvements in skin clearance and itch reduction. The authors emphasize the acceptable safety profile of the ointment, making it a promising new treatment option for psoriasis.

A New Oasis in the Desert of Psoriasis

This research offers a ray of hope for individuals struggling with plaque psoriasis. The findings demonstrate the potential of topical tofacitinib in effectively managing this chronic skin condition. It’s like finding a cool oasis in the middle of a scorching desert, offering relief from the relentless itch and inflammation.

Navigating the Desert of Psoriasis

This research highlights the importance of exploring new and effective treatment options for psoriasis. The authors emphasize the potential of topical tofacitinib as a safe and effective alternative for individuals with mild to moderate plaque psoriasis. It’s like having a reliable guide to navigate the desert of psoriasis, helping individuals find relief and manage this chronic condition.

Dr. Camel's Conclusion

This research provides encouraging evidence for the use of topical tofacitinib in managing plaque psoriasis. The findings suggest that this new treatment option offers a safe and effective approach to reducing itch and improving skin clearance. This research is like a refreshing oasis in the desert, providing a much-needed source of hope and relief for individuals struggling with this chronic skin condition.

Date :
  1. Date Completed 2017-12-06
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27716172

DOI: Digital Object Identifier

PMC5048458

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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