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Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity.

Author: ArjinajarnPhatchawan, ChatsudthipongVaranuj, ChattipakornNipon, JaikumkaoKrit, LungkaphinAnusorn, PongchaidechaAnchalee, ThongnakLa-Ongdao, WanchaiKeerati

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Atorvastatin, a statin drug, has a protective effect against gentamicin-induced nephrotoxicity in rats. This effect was more pronounced when atorvastatin was administered concurrently with or prior to gentamicin treatment.
Paper Details　
Original Abstract of the Article :
Gentamicin is a commonly used aminoglycoside antibiotic. However, its therapeutic use is limited by its nephrotoxicity. The mechanisms of gentamicin-induced nephrotoxicity are principally from renal inflammation and oxidative stress. Since atorvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductas...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058561/

データ提供：米国国立医学図書館（NLM）

A New Oasis for Gentamicin-Induced Nephrotoxicity: Atorvastatin

Gentamicin is a powerful antibiotic, but like a harsh desert wind, it can sometimes cause nephrotoxicity. This research is like a journey through the desert of gentamicin-induced nephrotoxicity, exploring the potential benefits of atorvastatin as a protective agent. The authors investigated the effects of atorvastatin on renal inflammation, endoplasmic reticulum stress, and apoptosis in rats treated with gentamicin. They sought to determine whether atorvastatin could mitigate the damaging effects of gentamicin on the kidneys.

Atorvastatin Shows Promise for Protecting Against Nephrotoxicity

This research is like a desert oasis, offering a refreshing perspective on managing gentamicin-induced nephrotoxicity. The authors found that atorvastatin, when administered before or after gentamicin treatment, significantly reduced renal inflammation, endoplasmic reticulum stress, and apoptosis in rats. These findings suggest that atorvastatin could be a valuable tool for preventing or mitigating the harmful effects of gentamicin on the kidneys.

A Potential Solution for Gentamicin-Induced Nephrotoxicity

This research is a reminder that even in the face of potential side effects, there are ways to protect patient health. Atorvastatin could offer a new avenue for mitigating the damaging effects of gentamicin on the kidneys, potentially reducing the risk of complications and improving patient outcomes.

Dr. Camel's Conclusion

This research provides valuable insights into the protective effects of atorvastatin against gentamicin-induced nephrotoxicity. The authors' findings suggest that atorvastatin could be a valuable tool for mitigating the harmful effects of gentamicin on the kidneys, potentially improving patient safety and reducing the risk of complications. This research is a testament to the ongoing search for ways to minimize the side effects of medications and improve patient care.
Date :
  1. Date Completed 2017-05-09
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

27727327

DOI: Digital Object Identifier

PMC5058561

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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