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Novel Levodopa Formulations for Parkinson's Disease.

Author: FoxSusan H, FreitasMaria Eliza, Ruiz-LopezMarta

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review summarizes the pharmacokinetic aspects, clinical efficacy, and potential adverse events of novel levodopa formulations currently available or under development for Parkinson's disease.
Paper Details　
Original Abstract of the Article :
Levodopa remains the most effective treatment for Parkinson's disease and is considered the gold standard therapy. However, disease progression and changes in the gastrointestinal tract result in a declining window of treatment response in a majority of patients. Efforts have been made recently to i...See full text at original site
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引用元：
https://doi.org/10.1007/s40263-016-0386-8

データ提供：米国国立医学図書館（NLM）

Novel Levodopa Formulations for Parkinson's Disease

Parkinson's disease, characterized by tremors and movement difficulties, presents a formidable challenge for researchers seeking effective treatments. This study explores the ongoing quest for improved levodopa formulations, the cornerstone therapy for Parkinson's disease. The study delves into the challenges of declining treatment response due to disease progression and gastrointestinal changes. It examines the potential of novel formulations to improve levodopa bioavailability, including oral, intestinal, transcutaneous, and inhaled approaches. The study highlights the promising potential of these new formulations to enhance treatment effectiveness and patient outcomes.

Reimagining Levodopa Delivery: A Quest for Improved Outcomes

The study's analysis of various levodopa formulations showcases the dynamic nature of Parkinson's disease research. The development of new formulations, such as IPX066 and levodopa-carbidopa intestinal gel (LCIG), represents a significant step forward in managing the disease.

A Journey Through the Shifting Sands of Parkinson's Treatment

Navigating the complexities of Parkinson's disease treatment is akin to traversing a vast and ever-changing desert. This study illuminates the importance of ongoing research to develop new and improved formulations, ultimately offering hope for better patient outcomes. The quest for improved levodopa delivery continues, driven by the desire to provide patients with the most effective and tolerable treatment options.

Dr. Camel's Conclusion

The development of novel levodopa formulations is a promising sign in the battle against Parkinson's disease. The study's exploration of these new therapies offers hope for better management of symptoms, improved quality of life, and enhanced patient outcomes.

Date :
  1. Date Completed 2018-01-08
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27743318

DOI: Digital Object Identifier

10.1007/s40263-016-0386-8

Related Literature

Article Analysis
・Effects of levodopa oral inhalation
SNS
PICO Info
in preparation
Languages

English

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