Comparison of the effects of esomeprazole 40 mg, rabeprazole 20 mg, lansoprazole 30 mg, and pantoprazole 40 mg on intragastrıc pH in extensive metabolizer patients with gastroesophageal reflux disease.

Author: AydınDinçer, HülagüSadetin, KocamanOrhan, KondukBuğra Tolga, ÇelebiAltay, ŞentürkÖmer

Paper Details 
Original Abstract of the Article :
Studies on the therapeutic efficacy of proton pump inhibitors (PPIs) in patients with gastroesophageal reflux disease (GERD) have been recently published. In most of these studies, comparison of only two PPIs have been made. There are few studies on the comparison of four or more PPIs. We aimed to c...See full text at original site
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引用元:
https://doi.org/10.5152/tjg.2016.15514

データ提供:米国国立医学図書館(NLM)

Comparing the Effects of Different Proton Pump Inhibitors on Gastric pH

This research delves into the field of gastroenterology, specifically focusing on the efficacy of proton pump inhibitors (PPIs), a class of medications commonly used to reduce stomach acid production. The researchers conducted a comparative study to evaluate the acid-inhibitory effects of four different PPIs: esomeprazole, rabeprazole, lansoprazole, and pantoprazole. They aimed to determine how these PPIs differed in their ability to raise gastric pH, a measure of stomach acid levels, in patients with gastroesophageal reflux disease (GERD).

PPIs Show Varied Effects on Gastric pH

The study revealed that the four PPIs investigated exhibited differences in their effects on gastric pH. While all four PPIs were effective in raising gastric pH, there were variations in the magnitude and duration of their effects. These findings provide valuable insights for healthcare providers who are choosing the most appropriate PPI for individual patients with GERD. The study underscores the importance of considering individual patient factors, such as genetic variations in drug metabolism, when selecting a PPI.

Choosing the Right PPI for Your Needs

This research highlights the importance of discussing your medication options with your healthcare provider, especially when considering PPIs. Just as a camel adapts to the challenges of different desert environments, individuals respond differently to medications. It's essential to consider your individual needs, preferences, and any potential interactions with other medications when choosing a PPI.

Dr.Camel's Conclusion

This study underscores the importance of individualized medicine, even when it comes to seemingly simple medications like PPIs. It reminds us that the world of medicine, like a vast desert, is full of nuances and individual variations. The study's findings highlight the need for careful consideration of patient factors and open communication with healthcare providers when choosing the most appropriate treatment.

Date :
  1. Date Completed 2017-10-03
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27782887

DOI: Digital Object Identifier

10.5152/tjg.2016.15514

Related Literature

SNS
PICO Info
in preparation
Languages

English

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