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Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
Author: GillenMichael, HarmonErin, KerrBradley, LeeCaroline A, NguyenMai, ShenZancong, TieuKathy, WilsonDavid M
Original Abstract of the Article :
Lesinurad is a selective uric acid reabsorption inhibitor approved in the United States and Europe for treatment of gout in combination with a xanthine oxidase inhibitor. A maximum tolerated dose study was conducted to determine the lesinurad supratherapeutic dose, followed by a thorough QTc study t...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096775/
データ提供:米国国立医学図書館(NLM)
Lesinurad: A New Approach to Gout Management
The world of [rheumatology] is constantly seeking new and effective treatments for [gout], a painful inflammatory condition. This study investigates the effects of [lesinurad], a [selective uric acid reabsorption inhibitor], on [cardiac repolarization]. It's like exploring a desert where a hidden oasis may hold the key to a cure; we need to carefully evaluate the potential benefits and risks of new treatments.
Lesinurad's Impact on Cardiac Repolarization
The researchers conducted a [thorough QTc study] to assess the impact of [lesinurad] on [cardiac repolarization]. This is like carefully examining the terrain of the desert before embarking on a journey; we need to understand the potential consequences of new treatments.
Managing Gout While Protecting the Heart
This research provides valuable insights into the [cardiac safety] of [lesinurad], a promising new treatment for [gout]. It's like finding a path through the desert that avoids dangerous sandstorms; we need to choose treatments that are both effective and safe for our hearts.
Dr.Camel's Conclusion
This study is a testament to the ongoing efforts to find safer and more effective treatments for [gout]. It's like finding a hidden oasis in the desert of medical research; every step forward brings us closer to a healthier future for patients suffering from this painful condition.
Date :
- Date Completed 2017-05-17
- Date Revised 2018-11-13
Further Info :
Related Literature
English
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