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Anticonvulsant effects of isomeric nonimidazole histamine H<sub>3</sub> receptor antagonists.
Author: SaadAli, SadekBassem, SchwedJohannes Stephan, StarkHolger, WalterMiriam, WeizelLilia
Original Abstract of the Article :
Phenytoin (PHT), valproic acid, and modern antiepileptic drugs (AEDs), eg, remacemide, loreclezole, and safinamide, are only effective within a maximum of 70%-80% of epileptic patients, and in many cases the clinical use of AEDs is restricted by their side effects. Therefore, a continuous need remai...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106240/
データ提供：米国国立医学図書館（NLM）
Histamine H3 Receptor Antagonists: A New Oasis in the Desert of Epilepsy
Epilepsy, a neurological disorder characterized by seizures, is like a chaotic desert, where unpredictable storms of brain activity can disrupt daily life. Current antiepileptic drugs (AEDs) are often ineffective or have unpleasant side effects, leaving many patients seeking alternative solutions. This study focuses on histamine H3 receptor antagonists, exploring their potential as a new class of AEDs, hoping to create a more stable and manageable environment for those living with epilepsy.
Histamine H3 Receptor Antagonists: A Promising Path in the Desert of Epilepsy
The researchers investigated the anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists in animal models. They discovered that some of these antagonists exhibited significant anticonvulsant activity, suggesting their potential as novel AEDs. This is like finding a new pathway in the vast desert of epilepsy, one that could offer a more effective and targeted approach to managing seizures.
Seeking a Sustainable Oasis in the Epilepsy Desert
This study highlights the potential of targeting histamine H3 receptors as a novel strategy for epilepsy treatment. Further research is needed to develop safe and effective drugs based on these findings. It's a journey of discovery, seeking out new oases of knowledge to find more effective and sustainable solutions for those living with epilepsy.
Dr.Camel's Conclusion
The search for effective epilepsy treatments is a journey across a vast and challenging desert. Histamine H3 receptor antagonists offer a promising new oasis, providing hope for a more stable and manageable future for those living with this condition.
Date :
- Date Completed 2017-04-26
- Date Revised 2018-11-13
Further Info :
Related Literature
English
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