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Evaluation of tolerability with the co-formulation elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate for post-HIV exposure prophylaxis.
Author: AnthonyTheresita, CampaPauline, DaguenelAnne, FonquernieLaurent, GirardPierre Marie, GuiguetMarguerite, MeyohasMarie Caroline, ValinNadia
Original Abstract of the Article :
Label="BACKGROUND">The preferred regimen for HIV post-exposure prophylaxis (PEP) is based mainly on safety and tolerability because it is given to immunocompetent people without HIV infection for a limited time (28 days). The frequency of adverse events (AEs) may be > 60%. Althou...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127047/
データ提供:米国国立医学図書館(NLM)
Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Fumarate for Post-HIV Exposure Prophylaxis: A Tolerability Evaluation
We're navigating the treacherous landscape of [HIV post-exposure prophylaxis (PEP)], a critical intervention for individuals who might have been exposed to the virus. This research explores the tolerability of a specific drug combination, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate, or Stribild, as a potential shield against HIV infection. The study focuses on the [tolerability] aspect, as the success of PEP relies heavily on adherence to the treatment regimen.
The study finds that Stribild is generally well-tolerated, despite the high frequency of adverse events, which can be likened to encountering occasional bumps and hurdles in the desert journey. While these events are usually not severe, they can lead to treatment interruptions, which is like taking a detour on the path to HIV prevention.
Balancing Effectiveness and Safety
The study emphasizes the importance of balancing effectiveness and safety in PEP treatments. Stribild's good tolerability profile suggests it could be a valuable addition to the PEP arsenal, but careful monitoring and patient education are crucial for maximizing its efficacy. It's like finding a safe passage through a desert, but the journey requires careful planning and attention to detail.
Stribild: A Promising Option
This research is like a well-worn path in the desert of HIV prevention, providing evidence for the potential of Stribild as a safe and tolerable option for PEP. With continued research and a focus on patient education, this drug could play a significant role in protecting individuals from the devastating consequences of HIV infection.
Dr.Camel's Conclusion
Navigating the world of HIV prevention is a constant quest for better, safer, and more effective interventions. This research is like a compass guiding us towards a safer path, emphasizing the need for continued research to ensure that those at risk have access to the most appropriate and effective treatments. It's a journey through a complex and ever-changing desert, but with a clear understanding of the terrain and its challenges, we can pave the way for a healthier future.
Date :
- Date Completed 2017-06-12
- Date Revised 2018-12-02
Further Info :
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