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Intravenous Amisulpride for the Prevention of Postoperative Nausea and Vomiting: Two Concurrent, Randomized, Double-blind, Placebo-controlled Trials.

Author: BergeseSergio D, CandiottiKeith A, ChassardDominique, DiemunschPierre, EberhartLeopold, FoxGabriel, GanTong J, KovacAnthony L, KrankePeter, LeimanDavid G, MelsonTimothy I, MinkowitzHarold S, MotschJohann

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Amisulpride was safe and superior to placebo in reducing the incidence of postoperative nausea and vomiting in adult inpatients at moderate to high risk of postoperative nausea and vomiting.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Two essentially identical, randomized, double-blind, placebo-controlled, parallel-group phase III studies evaluated the efficacy of intravenous amisulpride, a dopamine D2/D3 antagonist, in the prevention of postoperative nausea and vomiting in adult surgical patients. METHODS: Adult inp...See full text at original site
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引用元：
https://doi.org/10.1097/ALN.0000000000001458

データ提供：米国国立医学図書館（NLM）

Amisulpride for Postoperative Nausea and Vomiting: A Promising Solution

Postoperative nausea and vomiting (PONV) is a common and unpleasant side effect of surgery. This study examines the effectiveness of intravenous amisulpride, a dopamine antagonist, for the prevention of PONV in adult surgical patients. It's like finding a reliable shield against a desert sandstorm – a way to protect patients from the discomfort and complications of PONV. The researchers conducted two randomized, double-blind, placebo-controlled trials to compare the effects of amisulpride with placebo. They found that [main findings], suggesting that amisulpride may be a safe and effective treatment for preventing PONV. This research is significant because [key result].

A New Shield Against PONV: Amisulpride Shows Promise

This research shows that [research results], offering a new option for preventing PONV and improving patient comfort after surgery.

Managing PONV: A Multi-faceted Approach

This research highlights the importance of managing PONV effectively to enhance patient recovery and improve their overall experience after surgery. It's essential to discuss your risk factors for PONV with your doctor and explore potential prevention strategies before surgery.

Dr. Camel's Conclusion

This research offers a ray of hope for patients struggling with PONV. It's like discovering a new oasis in the desert, providing much-needed relief and comfort after surgery. Amisulpride shows promise as a safe and effective treatment for preventing PONV, offering a new approach to managing this common post-surgical challenge.

Date :
  1. Date Completed 2017-06-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27902493

DOI: Digital Object Identifier

10.1097/ALN.0000000000001458

Related Literature

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・Effects of amisulpride injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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