Loperamide, the "Poor Man's Methadone": Brief Review.

Author: GnanasegaramSamantha A, StanciuCornel N

Paper Details 
Original Abstract of the Article :
Loperamide is widely available as an inexpensive, over-the-counter remedy commonly used for management of diarrhea. Although an opioid, at therapeutic doses it acts primarily on the gastrointestinal tissues; however, larger than recommended amounts facilitate central nervous system (CNS) penetration...See full text at original site
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引用元:
https://doi.org/10.1080/02791072.2016.1260188

データ提供:米国国立医学図書館(NLM)

Loperamide: A Double-Edged Sword in the Desert of Opioid Use

The world of opioid use is a complex and challenging desert landscape, fraught with dangers. This review, like a guidebook through treacherous territory, examines the use of loperamide, an over-the-counter antidiarrheal medication, as a substitute for methadone, a prescription opioid used for pain management and opioid addiction treatment. The review highlights the potential for loperamide misuse, which can lead to serious health complications, like a desert traveler venturing into uncharted territory.

Loperamide's Dark Side: A Mirage of Relief

While loperamide is generally safe when used as directed, high doses can bypass the gastrointestinal tract and reach the brain, mimicking the effects of opioids, like a mirage that appears to offer relief but ultimately leads to dehydration. This misuse can lead to tolerance, withdrawal symptoms, and even life-threatening cardiac arrhythmias.

Navigating the Desert of Opioid Misuse: A Call for Vigilance

This review underscores the importance of responsible medication use and the dangers of misuse. It emphasizes the need for healthcare providers to be vigilant in identifying loperamide misuse and to educate patients about the risks associated with this medication. This is a crucial journey in the desert of opioid use, where awareness and education are essential tools for safe passage.

Dr. Camel's Conclusion

This review, like a signpost in the desert, warns of the dangers of loperamide misuse. It serves as a reminder that even seemingly harmless medications can pose risks when used improperly.

Date :
  1. Date Completed 2017-12-07
  2. Date Revised 2019-02-21
Further Info :

Pubmed ID

27918873

DOI: Digital Object Identifier

10.1080/02791072.2016.1260188

Related Literature

SNS
PICO Info
in preparation
Languages

English

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