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Targeting the Hedgehog Pathway for Locally Advanced and Metastatic Basal Cell Carcinoma.

Author: EsmaeliBita, YinVivian T

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vismodegib and sonidegib, two sonic hedgehog inhibitors, have shown a response rate of around 50% in patients with locally advanced or metastatic basal cell carcinoma. The most common side effects are muscle cramps, weight loss, fatigue, and loss of appetite. Resistance to these drugs can occur due to SMO mutations or activation of the RAS/MAPK pathway. New research focuses on dual inhibition to overcome this resistance.
Paper Details　
Original Abstract of the Article :
Basal cell caricnoma (BCC), the most common periocular magliancy, is treated with complete surgical excision. However, in patients not amenable to surgery or when surgical resection means loss of vital organs or disfiguring procedures due to locally advanced or metastatic disease, targeting the hedg...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27928965

データ提供：米国国立医学図書館（NLM）

Targeting the Hedgehog Pathway for Basal Cell Carcinoma

Basal cell carcinoma (BCC), the most common skin cancer, is typically treated with surgical excision. However, for patients with locally advanced or metastatic BCC, targeting the hedgehog pathway offers a promising alternative treatment approach. This review discusses the use of hedgehog pathway inhibitors, such as vismodegib and sonidegib, in managing advanced BCC.

Navigating the Desert of BCC Treatment

This review, like a camel traversing the vast desert of BCC treatment options, explores the potential of targeting the hedgehog pathway. The authors delve into the use of hedgehog pathway inhibitors, offering insights into their efficacy and potential side effects.

Hope for Advanced BCC: A New Oasis in the Desert

The study's findings, like a shimmering oasis in the desert of advanced BCC treatment, highlight the potential of hedgehog pathway inhibitors to provide effective management options for patients who are not candidates for surgery. The review offers valuable information to guide clinicians in considering this novel treatment approach.

Dr.Camel's Conclusion

This review underscores the importance of exploring new treatment avenues for advanced BCC. Targeting the hedgehog pathway offers a promising alternative for patients who are not candidates for surgery. Like a camel adapting its journey to navigate the challenging terrain of the desert, researchers and clinicians must be open to exploring innovative approaches to treat this complex disease.

Date :
  1. Date Completed 2017-12-22
  2. Date Revised 2018-06-05
Further Info :

Pubmed ID

27928965

DOI: Digital Object Identifier

CPD-EPUB-80219

Related Literature

Article Analysis
・Side Effects of sonidegib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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