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M1 muscarinic receptors are necessary for retrieval of remote context fear memory.

Author: OliveiraMaria Gabriela Menezes, PatricioRafael Rodisanski, SoaresJuliana Carlota Kramer

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dicyclomine, an M1 muscarinic receptor antagonist, impaired the retrieval of remote memories in a fear conditioning task in rats, suggesting a role of muscarinic receptors in remote memory retrieval.
Paper Details　
Original Abstract of the Article :
Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully und...See full text at original site
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引用元：
https://doi.org/10.1016/j.physbeh.2016.12.008

データ提供：米国国立医学図書館（NLM）

M1 Muscarinic Receptors are Necessary for Retrieval of Remote Context Fear Memory

This study investigates the role of [M1 muscarinic receptors] in the retrieval of [remote context fear memory] in rats. The researchers explored the effects of [dicyclomine], an [M1 muscarinic receptor antagonist], on memory retrieval in fear conditioning tasks. Their findings provide valuable insights into the neurobiological mechanisms underlying the retrieval of remote memories, a critical aspect of learning and memory.

Muscarinic Receptors and Memory Retrieval

The study's results demonstrate that [dicyclomine] impaired the retrieval of [remote context fear memory] in rats. This finding suggests that [M1 muscarinic receptors] are essential for the retrieval of remote memories, particularly those associated with fear conditioning. This research highlights the complex interplay between neurotransmitter systems and memory processes.

Understanding the Mechanisms of Memory

The study's findings contribute to our understanding of the neurobiological basis of [memory retrieval]. The research suggests that [M1 muscarinic receptors] play a critical role in the retrieval of remote memories, particularly those associated with fear conditioning. This information is crucial for developing future therapies that target memory processes and address disorders related to memory impairment.

Dr. Camel's Conclusion

The intricate mechanisms of memory are like a vast desert landscape, with each sand dune representing a different aspect of the memory process. This research offers a closer look at the role of [M1 muscarinic receptors] in the retrieval of remote memories. Understanding these pathways is essential for navigating the complex world of memory and developing effective treatments for those experiencing memory impairment.

Date :
  1. Date Completed 2017-06-28
  2. Date Revised 2018-07-10
Further Info :

Pubmed ID

27940145

DOI: Digital Object Identifier

10.1016/j.physbeh.2016.12.008

Related Literature

Article Analysis
・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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