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[Pharmacokinetics of antimicrobial agents in the elderly].

Author: AdachiS, SuzukiK, YamamotoK, YamamotoT

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The pharmacokinetics of several antibiotics in the elderly should be considered when choosing antibiotics for elderly patients. Elderly patients may have reduced renal function, leading to prolonged half-life and increased area under the curve (AUC) of the drugs.
Paper Details　
Original Abstract of the Article :
The elderly can be easily infected by certain organisms due to underlying diseases and complications. The pharmacokinetics of cefotiam, ceftriaxone, ceftizoxime, cefpodoxime proxetil, carumonam, clarithromycin, amikacin, ofloxacin and lomefloxacin in the elderly should be considered when choosing an...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2795964

データ提供：米国国立医学図書館（NLM）

Pharmacokinetics of Antimicrobial Agents in the Elderly: A Camel's Journey Through the Desert of Aging

The desert of aging is a vast and ever-changing landscape, with unique challenges and considerations for individuals as they age. This research focuses on the pharmacokinetics of antimicrobial agents in the elderly, a population often at increased risk for infections. The study examines the differences in drug absorption, distribution, metabolism, and excretion in older adults, aiming to optimize antibiotic therapy for this vulnerable group.

The study found that the pharmacokinetics of various antimicrobial agents, including cefotiam, ceftriaxone, ceftizoxime, and amikacin, are often altered in the elderly, potentially leading to prolonged half-lives and increased drug accumulation. These findings highlight the need for dosage adjustments and careful monitoring to ensure effective and safe antibiotic therapy in older adults.

Navigating the Desert of Aging: A Camel's Perspective

As a camel, I have witnessed the resilience and adaptability of animals in the desert as they age. This research highlights the importance of adjusting our approach to healthcare as we age. It reminds us that medication dosages and treatment plans may need to be tailored to the unique needs of older individuals to ensure optimal outcomes.

The Desert of Aging: A Journey Through Science and Personalized Medicine

This research emphasizes the importance of personalized medicine in tailoring antibiotic therapy for older adults. By taking into account the unique pharmacokinetic changes that occur with aging, we can ensure that antimicrobial agents are used safely and effectively to treat infections in this vulnerable population.

Dr. Camel's Conclusion

This research underscores the importance of considering the unique pharmacokinetic changes that occur with aging when prescribing antimicrobial agents to older adults. By optimizing drug doses and monitoring for potential side effects, we can ensure that antibiotics are used safely and effectively to treat infections in this vulnerable population.

Date :
  1. Date Completed 1989-10-30
  2. Date Revised 2011-07-29
Further Info :

Pubmed ID

2795964

DOI: Digital Object Identifier

2795964

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Languages

Japanese

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