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Stimulation of Suicidal Erythrocyte Death by Ceritinib-Treatment of Human Erythrocytes.
Author: Al Mamun BhuyanAbdulla, BissingerRosi, LangFlorian, SignorettoElena
Original Abstract of the Article :
The anaplastic lymphoma kinase (ALK) inhibitor ceritinib is utilized for the treatment of ALK positive non-small cell lung carcinoma. Side effects of the drug include decrease of blood hemoglobin concentration. Possible causes of anemia include stimulation of suicidal erythrocyte death or eryptosis,...See full text at original site
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引用元:
https://doi.org/10.1159/000453167
データ提供:米国国立医学図書館(NLM)
Ceritinib and Erythrocytes: A Complex Interaction in the Fight Against Cancer
The field of cancer treatment, like a vast desert teeming with life and challenges, is constantly seeking new weapons to combat this formidable foe. This study delves into the world of ceritinib, a drug used to target ALK-positive non-small cell lung cancer. However, like a desert mirage, ceritinib has its own set of complexities and potential side effects.
This research, like an expedition into the intricate world of blood cells, aimed to investigate whether ceritinib could induce eryptosis, a form of programmed cell death in red blood cells. The researchers, like skilled desert guides, sought to understand the potential consequences of this drug on red blood cells and the overall health of patients.
Unveiling the Mechanism: A Complex Interaction Between Ceritinib and Red Blood Cells
The study revealed a complex interaction between ceritinib and red blood cells, like discovering a hidden network of pathways within a desert ecosystem. Ceritinib was found to trigger eryptosis, leading to a decrease in red blood cells. This finding, like a ripple effect in the desert, underscores the importance of carefully monitoring patients receiving this medication.
Navigating Cancer Treatment: Balancing Benefits and Risks
This research, like a map guiding us through the complexities of cancer treatment, highlights the importance of balancing the potential benefits of medication with its potential risks. The study encourages patients to have open conversations with their doctors about the potential side effects of treatment, like navigating a desert with a compass, ensuring that the path chosen is aligned with their individual needs and goals.
Dr. Camel's Conclusion
This research, like a journey through a desert, reminds us that even the most promising treatments can have unintended consequences. It emphasizes the importance of careful observation and monitoring in the fight against cancer, like navigating a desert with a keen eye for potential dangers.
Date :
- Date Completed 2017-02-06
- Date Revised 2019-02-12
Further Info :
Related Literature
English
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