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Formoterol and salbutamol metered aerosols: comparison of a new and an established beta-2-agonist for their bronchodilating efficacy in the treatment of childhood bronchial asthma.

Author: BerdelD, von BergA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Formoterol, a new beta-2-agonist, produced longer-lasting bronchodilation than salbutamol in young asthmatics. Both medications had a rapid onset of action and a comparable maximal effect, but formoterol's effect lasted for up to 8 hours.
Paper Details　
Original Abstract of the Article :
In this placebo-controlled, double-blind, single-dose study the new beta-2-agonist formoterol (one puff, 12 micrograms) was intraindividually compared with salbutamol (one puff, 100 micrograms) for onset, magnitude, and duration of bronchodilating efficacy in 15 young asthmatics aged 5 to 14 years w...See full text at original site
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引用元：
https://doi.org/10.1002/ppul.1950070207

データ提供：米国国立医学図書館（NLM）

Formoterol vs. Salbutamol: A Comparative Study of Bronchodilators in Childhood Asthma

In the realm of [pediatric pulmonology], [bronchodilators] play a critical role in managing [childhood bronchial asthma]. This study investigates the bronchodilating efficacy of two commonly used beta-2-agonists, [formoterol] and [salbutamol], in young asthmatics. The researchers conducted a placebo-controlled, double-blind, single-dose study, comparing the onset, magnitude, and duration of bronchodilation after inhaling these medications.

Formoterol's Endurance: A Longer-Lasting Bronchodilator

The study revealed that both formoterol and salbutamol effectively produce rapid bronchodilation. However, formoterol demonstrated a significantly longer duration of action, maintaining a greater decrease in [specific airway resistance (sRaw)] for up to 12 hours compared to salbutamol. These findings highlight the potential advantages of formoterol for managing asthma symptoms, potentially reducing the need for frequent medication administrations.

Navigating Asthma Management: Choosing the Right Bronchodilator

This research underscores the importance of considering the duration of action when selecting bronchodilators for children with asthma. Formoterol's prolonged effect may provide a more convenient and effective treatment strategy for some patients, potentially improving asthma control and quality of life. However, further research is needed to determine the optimal use of these medications in different asthma phenotypes and severity levels.

Dr.Camel's Conclusion

Just as a camel's ability to store water allows it to thrive in the desert, formoterol's prolonged bronchodilating effect provides a sustained source of relief for children with asthma. This research offers valuable insights into the nuances of bronchodilator efficacy, reminding us to choose the right tool for the job to ensure the best possible outcomes for our patients.

Date :
  1. Date Completed 1989-11-01
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

2797925

DOI: Digital Object Identifier

10.1002/ppul.1950070207

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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