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Thioridazine elicits potent antitumor effects in colorectal cancer stem cells.

Author: GongPing, LiuPengfei, WangYi, ZhangChen, ZhouNing, ZhouYulai

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Thioridazine (THIO) is an anti-anxiety and anti-psychotic drug that has been shown to suppress the growth of various cancer cells. This study investigated the effect of THIO on colorectal cancer stem cells (CSCs). It was found that THIO significantly suppressed the proliferation and invasion of colon CSCs and induced cell apoptosis in a concentration-dependent manner. THIO could be a promising agent for the treatment of colon cancer and should be investigated in future clinical studies.
Paper Details　
Original Abstract of the Article :
As a member of the phenothiazine family, thioridazine (THIO) is a potent anti-anxiety and anti-psychotic drug. Recent studies have reported that THIO could suppress the growth of several types of cancer cells. However, the effect of THIO on colorectal cancer stem cells (CSCs) has not been investigat...See full text at original site
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引用元：
https://doi.org/10.3892/or.2016.5313

データ提供：米国国立医学図書館（NLM）

Thioridazine's Potential as a Cancer Fighter

This exciting study explores the potential of a drug called thioridazine (THIO) as a weapon against colorectal cancer. The research focused on a particularly aggressive type of cancer cell, known as a cancer stem cell, and investigated THIO's ability to suppress their growth. The authors found that THIO effectively targeted these cancer stem cells, leading to significant reductions in proliferation and invasion, while simultaneously promoting cell death. This suggests that THIO could potentially be a valuable tool in the fight against colorectal cancer.

Fighting Cancer Stem Cells

The research suggests that THIO could be a powerful tool in the battle against colorectal cancer. The study's findings provide compelling evidence that THIO can effectively target and destroy cancer stem cells.

Hope on the Horizon for Colorectal Cancer Patients

The study's findings offer hope to patients battling colorectal cancer. While more research is needed, the potential of THIO as a treatment option is exciting.

Dr. Camel's Conclusion

This is an excellent example of how basic research can lead to potential breakthroughs in cancer treatment. The study's findings show promise for THIO as a potential treatment for colorectal cancer, and it's definitely worth exploring further. Remember, a camel's resilience in the desert is a metaphor for our own capacity to overcome challenges, and this research gives us hope for conquering cancer.

Date :
  1. Date Completed 2017-03-23
  2. Date Revised 2017-03-23
Further Info :

Pubmed ID

28000884

DOI: Digital Object Identifier

10.3892/or.2016.5313

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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