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Human leukocyte antigen and idiosyncratic adverse drug reactions.

Author: NaisbittDean J, UsuiToru

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

A clinical association between a specific human leukocyte antigen (HLA) allele and idiosyncratic adverse drug reactions (IADRs) is a strong indication that IADRs are mediated by the adaptive immune system. This study highlights the potential to utilize blood from healthy drug-naive volunteers to study the priming of naïve T-cells to drugs, leading to the development of assays that predict intrinsic immunogenicity of drugs and chemicals at the preclinical stage of drug development.
Paper Details　
Original Abstract of the Article :
A clinical association between a specific human leukocyte antigen (HLA) allele and idiosyncratic adverse drug reactions (IADRs) is a strong indication that IADRs are mediated by the adaptive immune system. For example, it is well-established that HLA-B*15:02 and HLA-B*57:01 are associated with carba...See full text at original site
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引用元：
https://doi.org/10.1016/j.dmpk.2016.11.003

データ提供：米国国立医学図書館（NLM）

Unmasking the Immune System's Role in Drug Reactions

The human body is an intricate network of interacting systems, and sometimes even seemingly innocuous substances can trigger complex and unexpected reactions. This research delves into the field of pharmacogenetics, exploring the link between specific human leukocyte antigen (HLA) alleles and idiosyncratic adverse drug reactions (IADRs). The researchers demonstrate a strong association between certain HLA alleles and specific drug reactions, suggesting a key role for the adaptive immune system in mediating these responses. This research provides a valuable framework for understanding the complex interplay between genes, drugs, and the immune system.

The Importance of Personalized Medicine in Drug Safety

This research highlights the crucial role of genetic factors in influencing individual responses to drugs. The identification of HLA alleles associated with specific IADRs opens the door to personalized medicine, where treatment plans are tailored to an individual's unique genetic makeup. This could potentially improve drug safety and minimize the risk of adverse reactions.

The Future of Drug Development: Predicting Immunogenicity

This study presents a promising avenue for future drug development. By utilizing blood samples from healthy individuals to study the priming of naïve T-cells to drugs, researchers can potentially predict the immunogenicity of new drugs in the preclinical stage. This could significantly enhance drug safety and accelerate the development of safer and more effective medications.

Dr.Camel's Conclusion

Imagine a desert sandstorm that can cause unexpected and sometimes dangerous reactions. This study is like discovering a hidden map that identifies specific sand dunes which trigger the most violent storms. This research helps us understand the immune system's role in drug reactions, paving the way for safer and more personalized medicine in the future. It's like having a map to navigate the vast and sometimes treacherous landscape of drug development.

Date :
  1. Date Completed 2017-08-18
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

28017537

DOI: Digital Object Identifier

10.1016/j.dmpk.2016.11.003

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English

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