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Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through Affinity Constants, Drug Release Kinetics, and Conformational Changes.

Author: AlarcónLiliana P, BaenaYolima, ManzoRubén H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the in vitro interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups. The results provide a physicochemical basis for understanding the effects of these drugs in cellular cultures and their potential clinical side effects.
Paper Details　
Original Abstract of the Article :
This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the reversibility of the interaction, and the effect on the secondary structure of the ma...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388140/

データ提供：米国国立医学図書館（NLM）

DNA and Drugs: A Delicate Dance

DNA, the blueprint of life, is a complex molecule, and its interaction with drugs is a fascinating and important area of research. This study explores the interaction between DNA and drugs containing basic groups, examining how these drugs bind to DNA and how this binding affects the structure of the molecule. It's like a delicate dance between two partners, each with its own unique characteristics.

Understanding DNA-Drug Interactions: A Key to New Therapies

This study provides valuable insights into the complex interplay between DNA and drugs. By understanding how drugs bind to DNA, researchers can develop new therapies that target specific genes or pathways, potentially leading to more effective and targeted treatments for various diseases.

DNA: A Complex Molecule with Far-Reaching Implications

This study highlights the crucial role of DNA in health and disease. It emphasizes the importance of continued research into DNA-drug interactions to develop new and innovative therapies that can benefit countless individuals.

Dr.Camel's Conclusion

Just as a camel adapts to its environment by interacting with its surroundings, drugs interact with DNA in a complex dance. This study sheds light on the intricate nature of these interactions, providing valuable insights for developing new and effective therapies.

Date :
  1. Date Completed n.d.
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

28054999

DOI: Digital Object Identifier

PMC5388140

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Languages

English

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