Paper Details

  1. Home
  2. Paper Details

Symptomatic treatments for amyotrophic lateral sclerosis/motor neuron disease.

Author: GaleaMary, KhanFary, NgLouisa, YoungCarolyn A

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This overview highlighted the lack of robust evidence in Cochrane Systematic Reviews on interventions to manage symptoms resulting from motor neuron disease (MND). The overview found that there is a significant gap in studies assessing the effectiveness of interventions for symptoms relating to MND, such as pseudobulbar emotional lability and cognitive and behavioural difficulties. More research with appropriate study designs, robust methodology, and of sufficient duration is needed to address the changing needs of people with MND and their caregivers associated with MND disease progression and mortality.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Motor neuron disease (MND), which is also known as amyotrophic lateral sclerosis (ALS), causes a wide range of symptoms but the evidence base for the effectiveness of the symptomatic treatment therapies is limited. OBJECTIVES: To summarise the evidence from Cochrane Systematic Reviews o...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469543/

データ提供：米国国立医学図書館（NLM）

A Deep Dive into Symptomatic Treatments for Amyotrophic Lateral Sclerosis/Motor Neuron Disease

In the vast desert of neurological disorders, amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), presents a formidable challenge. This research explores the effectiveness of symptomatic treatments for ALS, a condition that causes a wide array of debilitating symptoms. The authors meticulously analyzed data from Cochrane Systematic Reviews, employing a rigorous approach that involved assessing the methodological quality of the included reviews. Their findings offer valuable insights into the current landscape of ALS treatment.

The Need for Robust Evidence in ALS Treatment

The study highlights the lack of robust evidence supporting many interventions for managing ALS symptoms. This scarcity of evidence, particularly from randomized controlled trials (RCTs), is a common desert mirage in the field of ALS research. The nature of the disease makes it ethically challenging to conduct placebo-controlled trials for certain symptoms, such as pain, or to withhold essential multidisciplinary care. This presents a significant hurdle for researchers.

What This Research Means for ALS Patients and Caregivers

This study emphasizes the urgent need for more research, especially for symptoms like pseudobulbar emotional lability, cognitive, and behavioral difficulties, which are often neglected in ALS research. Future studies should utilize appropriate outcome measures that are sensitive to change and can accurately assess the impact of interventions on quality of life. For ALS patients and caregivers, this research underscores the importance of staying informed about the latest developments in treatment options and seeking guidance from healthcare professionals.

Dr.Camel's Conclusion

This study, like a shimmering oasis in the desert, provides valuable insights into the challenges and opportunities of managing ALS symptoms. The lack of robust evidence underscores the need for dedicated research in this area. It's like searching for a lost camel in a vast desert - persistence, knowledge, and the right tools are essential. I encourage researchers and healthcare professionals to continue their tireless efforts in pursuit of better treatments for those affected by ALS.

Date :
  1. Date Completed 2017-04-28
  2. Date Revised 2023-10-11
Further Info :

Pubmed ID

28072907

DOI: Digital Object Identifier

PMC6469543

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.