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QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization.

Author: DesaiA, KeirnsJ, KowalskiD, KoweyP R, LademacherC, MujaisS, ParkerB, SchneidkrautM J, TownsendR, WojtkowskiT, YamazakiT, YenM

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This phase I study evaluated the effects of isavuconazole on cardiac ion channels in vitro and cardiac repolarization clinically. Isavuconazole shortened the QT interval in a dose-dependent manner but was generally well tolerated. No cardiac safety signals were detected in a phase III study.
Paper Details　
Original Abstract of the Article :
The effects of isavuconazole (active moiety of isavuconazonium sulfate) on cardiac ion channels in vitro and cardiac repolarization clinically were assessed in a phase I, randomized, double-blind study in healthy individuals who received isavuconazole (after 2-day loading dose), at therapeutic or su...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485736/

データ提供：米国国立医学図書館（NLM）

Isavuconazole: A Camel's Journey Through the Desert of Cardiac Repolarization

This research explores the effects of isavuconazole on cardiac repolarization, a crucial aspect of heart function. The study investigates the impact of isavuconazole on cardiac ion channels both in vitro and in vivo, aiming to understand its potential effects on QT interval duration and cardiac safety. The authors meticulously analyzed the data to assess the relationship between isavuconazole dosage, plasma concentration, and QT interval duration, providing valuable insights for clinicians prescribing this antifungal agent.

A Shifting Desert: Isavuconazole's Impact on QT Interval

The study reveals that isavuconazole shortens the QT interval in a dose-dependent manner, suggesting a potential for QT prolongation in patients receiving this medication. The authors emphasize the need for careful monitoring of QT interval duration in patients receiving isavuconazole, particularly at higher doses. It's like navigating a shifting desert landscape: the effects of isavuconazole on QT interval can be unpredictable, requiring careful observation and attention.

Navigating the Oasis of Cardiac Safety: A Camel's Perspective

This research highlights the importance of considering the potential cardiac effects of medications, even those used for non-cardiac conditions. The study's findings underscore the need for careful monitoring of QT interval duration in patients receiving isavuconazole, particularly at higher doses. It's like navigating the vast and unforgiving desert of cardiac health: understanding the potential risks and taking appropriate precautions is essential for a safe and successful journey.

Dr.Camel's Conclusion

This study provides valuable insights into the potential cardiac effects of isavuconazole. It encourages clinicians to carefully monitor QT interval duration in patients receiving this medication, particularly at higher doses. It's like navigating a vast and unforgiving desert: understanding the potential risks and taking appropriate precautions is essential for a safe and successful journey.

Date :
  1. Date Completed 2017-05-30
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28074556

DOI: Digital Object Identifier

PMC5485736

Related Literature

Article Analysis
・Effects of isavuconazonium
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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