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Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.

Author: BarresBen A, BohlenChristopher J, ClarkJ David, CorderGregory, DickinsonJasmine R, LowSarah A, ScherrerGrégory, SotoudehChaudy, SypekElizabeth I, TawfikVivianne L, WangDong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Opioid tolerance and opioid-induced hyperalgesia (OIH) are major obstacles to effective pain management. This study shows that μ opioid receptors (MORs) expressed by primary afferent nociceptors are crucial for tolerance and OIH development. Deleting MORs specifically in nociceptors eliminates these side effects without affecting antinociception. Co-administration of a peripheral MOR antagonist, methylnaltrexone bromide, also effectively abrogates tolerance and OIH. These findings support the development of strategies that combine opioid agonists with peripheral MOR antagonists to maximize and sustain opioid analgesic efficacy.
Paper Details　
Original Abstract of the Article :
Opioid pain medications have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia and drive dose escalation. The cell types and receptors on which opioids act to initiate these maladaptive processes remain dispute...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28092666

データ提供：米国国立医学図書館（NLM）

Unraveling the Opioid Puzzle: A Journey Through the Brain's Pain Pathways

Opioids, while effective pain relievers, can also have detrimental side effects such as tolerance and hyperalgesia. This research delves into the intricate workings of the brain's pain pathways to identify the specific receptors and cell types responsible for these adverse effects. The study reveals that μ opioid receptors (MORs) expressed by nociceptors, the sensory neurons responsible for pain perception, play a crucial role in the development of opioid tolerance and hyperalgesia.

A New Target for Opioid Therapy

The findings of this research pinpoint the MORs on nociceptors as a key target for mitigating opioid tolerance and hyperalgesia. By specifically targeting these receptors, researchers may be able to develop new therapies that maximize the analgesic benefits of opioids while minimizing their adverse effects. It's like discovering a hidden spring in the desert, offering a way to quench thirst without the harmful effects of consuming salty water.

A Path Towards Safer Opioid Treatment

This research offers a glimmer of hope for individuals seeking effective pain relief while avoiding the debilitating consequences of opioid tolerance and hyperalgesia. By targeting the specific MORs on nociceptors, researchers can potentially develop new therapies that improve the safety and efficacy of opioid treatment. It's a journey through the brain's complex pain pathways, seeking to find a path towards safer and more effective pain management.

Dr.Camel's Conclusion

This study is a significant step forward in our understanding of opioid tolerance and hyperalgesia. By identifying the specific receptors and cell types involved, researchers are closer to developing novel strategies to maximize the benefits of opioids while minimizing their adverse effects. This research holds the potential to improve the lives of countless individuals struggling with chronic pain, providing a brighter future for opioid therapy.

Date :
  1. Date Completed 2017-08-14
  2. Date Revised 2023-10-31
Further Info :

Pubmed ID

28092666

DOI: Digital Object Identifier

NIHMS834527

Related Literature

Article Analysis
・Side Effects of methylnaltrexone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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