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Calcium signalling through L-type calcium channels: role in pathophysiology of spinal nociceptive transmission.

Author: AbyFranck, FossatPascal, LandryMarc, NagyFrédéric, RadwaniHouda, Roca-LapirotOlivier

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the role of L-type voltage-gated calcium channels in pain processes. It highlights the specific roles of Ca<sub>v</sub> 1.2 and Ca<sub>v</sub> 1.3 subtypes in short- and long-term sensitization to pain, and the potential of developing subtype-specific compounds to treat pathological pain with reduced side-effects.
Paper Details　
Original Abstract of the Article :
L-type voltage-gated calcium channels are ubiquitous channels in the CNS. L-type calcium channels (LTCs) are mostly post-synaptic channels regulating neuronal firing and gene expression. They play a role in important physio-pathological processes such as learning and memory, Parkinson's disease, aut...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980403/

データ提供：米国国立医学図書館（NLM）

Calcium Signaling: Decoding the Language of Pain in the Spinal Cord

The spinal cord, like a vast desert, is a complex network of neurons that transmit signals throughout the body. This study explores the role of L-type calcium channels in the pathophysiology of spinal nociceptive transmission, the process by which pain signals are sent from the periphery to the brain. It's like uncovering a hidden oasis of knowledge about how pain signals are relayed through this intricate network of nerves. The study reveals the intricate interplay between calcium signaling and pain perception, emphasizing the potential of targeting these channels for therapeutic purposes.

L-type Calcium Channels: A Key Player in Pain Perception

The study found that L-type calcium channels, specifically Cav 1.2 and Cav 1.3, are expressed in the dorsal horn of the spinal cord. These channels, like skilled camels traversing the desert, play a significant role in shaping pain perception. Cav 1.3 channels contribute to short-term sensitization to pain, while Cav 1.2 channels support the long-term sensitization that often follows nerve injury. This research provides valuable insights into the complex mechanisms underlying pain perception, paving the way for the development of new and more targeted pain therapies.

L-type Calcium Channels: A Potential Target for Pain Relief

This study, like a refreshing oasis in the desert of pain research, offers promising possibilities for the development of new pain therapies. By targeting specific subtypes of L-type calcium channels, we may be able to develop more effective and targeted treatments for chronic pain, offering relief to those who suffer from this debilitating condition. The research reminds us that the journey to understand and treat pain is an ongoing one, filled with both challenges and opportunities.

Dr.Camel's Conclusion

This research sheds light on the critical role of L-type calcium channels in pain perception. By understanding the specific mechanisms of these channels, we can develop more effective and targeted therapies for treating chronic pain, offering a glimmer of hope in the desert of pain.

Date :
  1. Date Completed 2019-08-06
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

28214378

DOI: Digital Object Identifier

PMC5980403

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Languages

English

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