Real-World Effectiveness and Safety of Oral Combination Antiviral Therapy for Hepatitis C Virus Genotype 4 Infection.

Author: , AmpueroJavier, ArenasJuan, ButiMaria, CabezasJoaquin, CallejaJose Luis, CrespoJavier, FernándezInmaculada, García-SamaniegoJavier, GeaFrancisco, Hernández-CondeMarta, JorqueraFrancisco, LensSabela, MolinaEsther, Moreno-PlanasJosé Maria, MorillasRosa Maria, MoyaAdolfo Gallego, NavascuésCarmen A, PascasioJuan Manuel, PrietoMartin, RincónDiego, Ruiz-AntoránBelén, SacristanBegoña, SalcinesJose Ramon, Sanchez RuanoJuan Jose, Sáez-RoyuelaFederico, TurnesJuan

Paper Details 
Original Abstract of the Article :
Patients with hepatitis C virus (HCV) genotype 4 infection are poorly represented in clinical trials of second-generation direct-acting antiviral agents (DAAs). More data are needed to help guide treatment decisions. We investigated the effectiveness and safety of DAAs in patients with genotype 4 in...See full text at original site
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引用元:
https://doi.org/10.1016/j.cgh.2017.02.020

データ提供:米国国立医学図書館(NLM)

Treating Hepatitis C: A Real-World Look at Effectiveness and Safety

The treatment of [hepatitis C virus (HCV)] infection is constantly evolving with the development of new [direct-acting antiviral agents (DAAs)]. This study examines the real-world effectiveness and safety of these medications in patients with [HCV genotype 4 infection], a population often underrepresented in clinical trials. The researchers analyzed data from a national database to evaluate the outcomes of [OMV/PTVr + RBV] and [LDV/SOF ± RBV] regimens in this patient group. The findings demonstrate that both regimens achieved high rates of [sustained virologic response at Week 12 post treatment (SVR12)], indicating their effectiveness in [clearing HCV infection]. Furthermore, the study highlights the safety profile of both regimens, showing comparable rates of [serious adverse events (SAEs)] to those reported for other HCV genotypes.

Real-World Evidence for HCV Treatment

This study provides valuable real-world evidence on the effectiveness and safety of [DAAs] in [HCV genotype 4 infection]. The research suggests that these regimens offer a viable treatment option for this patient population, demonstrating comparable efficacy and safety profiles to those observed in clinical trials. This information can help guide treatment decisions for individuals with [HCV genotype 4 infection] in routine practice.

Managing Hepatitis C

For individuals with [HCV infection], staying informed about the latest treatment advancements and potential side effects is crucial. Close communication with your healthcare provider is vital to ensure that you receive the most appropriate treatment for your specific needs. This research highlights the importance of real-world data in evaluating the effectiveness and safety of new therapies.

Dr.Camel's Conclusion

Imagine a camel trekking across a vast desert, its journey guided by the stars above. This research offers a similar sense of direction in the treatment of [HCV]. The study provides real-world evidence about the effectiveness and safety of [DAAs], akin to a reliable map guiding patients towards a healthier future. However, like a desert that holds secrets, this research encourages further investigation to fully understand the long-term effects of these therapies.

Date :
  1. Date Completed 2018-02-12
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

28238958

DOI: Digital Object Identifier

10.1016/j.cgh.2017.02.020

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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