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Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.

Author: BaileyJustin J, Bernard-GauthierVadim, FarrellKristen, SchirrmacherRalf

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Trk receptors play important roles in neuronal development and function. Trk inhibitors are being developed for treating cancer and pain. This review discusses the growing number of structural classes of Trk inhibitors and the clinical research being conducted. While showing potential in treating certain cancers and pain, Trk inhibitors can cause adverse effects in the central nervous system, highlighting the need for further research into their safety profile.
Paper Details　
Original Abstract of the Article :
TrkA/B/C receptor activation supports growth, survival, and differentiation of discrete neuronal populations during development, adult life, and ageing but also plays numerous roles in human disease onset and progression. Trk-specific inhibitors have therapeutic applications in cancer and pain and t...See full text at original site
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引用元：
https://doi.org/10.1080/13543776.2017.1297797

データ提供：米国国立医学図書館（NLM）

Targeting the Trk Family: A New Frontier in Cancer and Pain Treatment

The Trk family of receptors, like a group of interconnected neurons, plays a crucial role in various physiological processes, including cell growth, survival, and differentiation. This research delves into the world of Trk inhibitors, exploring their potential for treating cancer and chronic pain. The authors review the latest developments in Trk inhibitor research, highlighting the growing number of structural classes and industrial entrants in this field.

A Multifaceted Approach: Expanding the Therapeutic Landscape

The authors highlight the significant progress made in the development of Trk inhibitors over the past six years. This research demonstrates the potential of targeting specific Trk receptors to combat a wide range of diseases, including cancer and chronic pain. It's like finding a hidden spring in the desert, offering a fresh source of therapeutic options for a variety of health challenges.

Navigating the Terrain: Challenges and Opportunities

The authors discuss the potential for adverse central nervous system side effects with Trk inhibitors, emphasizing the need for careful consideration during drug development. They also highlight the importance of understanding drug penetration into the brain. This underscores the importance of careful navigation through the complexities of drug development, balancing potential benefits with potential risks. It's like planning a journey across a vast desert, carefully mapping the terrain and anticipating potential obstacles.

Dr.Camel's Conclusion

This review provides a comprehensive overview of the latest developments in Trk inhibitor research, highlighting the potential of these drugs for treating cancer and chronic pain. It underscores the importance of continued research to optimize Trk inhibitor development, ensuring that these promising therapies can be safely and effectively delivered to patients.

Date :
  1. Date Completed 2017-06-20
  2. Date Revised 2017-06-20
Further Info :

Pubmed ID

28270021

DOI: Digital Object Identifier

10.1080/13543776.2017.1297797

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