Treatment of Relapsed/Refractory Acute Myeloid Leukemia.

Author: BosePrithviraj, CortesJorge E, VachhaniPankit

Paper Details 
Original Abstract of the Article :
Approximately 40-45% of younger and 10-20% of older adults with acute myeloid leukemia (AML) will be cured with current standard chemotherapy. The outlook is particularly gloomy for patients with relapsed and/or refractory disease (cure rates no higher than 10%). Allogeneic hematopoietic stem cell t...See full text at original site
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引用元:
https://doi.org/10.1007/s11864-017-0456-2

データ提供:米国国立医学図書館(NLM)

Relapsed/Refractory AML: A Desert of Despair?

Acute myeloid leukemia (AML) is a type of blood cancer that can be a real challenge to treat. It’s like a sandstorm that sweeps through the body, disrupting the normal flow of blood cells. While chemotherapy can help many patients, a significant percentage relapse or become refractory, meaning the cancer comes back or doesn't respond to treatment. This is a situation that feels like wandering endlessly in a desolate desert, with few options for survival. This research explores the current state of treatment for relapsed/refractory AML, highlighting the desperate need for new therapies. Researchers are delving into the genetic makeup of AML, trying to understand the intricacies of this disease and develop targeted therapies. While there haven't been any new approved drugs for AML in decades, there are several promising candidates on the horizon, including CPX-351, midostaurin, venetoclax, and others. This is like finding a hidden spring of water in the desert, offering a potential lifeline for patients.

Hope on the Horizon: New Therapies Emerging

The study underscores the crucial role of clinical trials in treating relapsed/refractory AML. This is like a research expedition, seeking new paths to navigate the desert of disease. By studying the genetic makeup of AML, researchers can identify ‘actionable’ mutations, allowing for more targeted therapies. This research highlights the potential of personalized medicine, where treatments are tailored to the specific genetic characteristics of each patient. This is like creating a unique map for each traveler, guiding them through the treacherous terrain.

Harnessing the Power of Personalized Medicine

This research emphasizes the importance of personalized medicine in cancer treatment. Just like in a desert, different individuals need different strategies to survive. This is a crucial step towards a more effective and patient-centered approach to combating AML, especially in the challenging context of relapsed/refractory disease.

Dr.Camel's Conclusion

The research in this area is like a caravan crossing the desert. While the journey is long and arduous, the hope for new and effective treatments for relapsed/refractory AML is steadily growing. It’s a testament to the resilience of the human spirit and the unwavering dedication of researchers to finding solutions for even the most challenging medical conditions.

Date :
  1. Date Completed 2017-08-15
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

28286924

DOI: Digital Object Identifier

10.1007/s11864-017-0456-2

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