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An update on HLA alleles associated with adverse drug reactions.

Author: Fricke-GalindoIngrid, LLerenaAdrián, López-LópezMarisol

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Several HLA alleles have been linked to adverse drug reactions (ADRs), particularly those induced by carbamazepine, allopurinol, abacavir and nevirapine.
Paper Details　
Original Abstract of the Article :
Adverse drug reactions (ADRs) are considered as an important cause of morbidity and mortality. The hypersensitivity reactions are immune-mediated ADRs, which are dose-independent, unpredictable and have been associated with several HLA alleles. The present review aimed to describe HLA alleles that h...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28315856

データ提供：米国国立医学図書館（NLM）

The Role of HLA Alleles in Adverse Drug Reactions

This study explores the complex world of adverse drug reactions (ADRs), specifically focusing on the role of HLA alleles in hypersensitivity reactions. The researchers, like detectives meticulously investigating a case, are seeking to understand the genetic factors that contribute to these unpredictable and often severe reactions. They delve into the vast literature on HLA alleles and their association with ADRs, providing a comprehensive overview of the current understanding of this complex phenomenon.

Unmasking the Genetic Roots of ADRs

This study highlights the importance of considering genetic factors when evaluating ADRs. It underscores the value of HLA screening in identifying individuals at risk for severe reactions to certain medications, especially for drugs known to be associated with HLA-related hypersensitivity. This is like discovering a hidden map that reveals the genetic landscape of ADRs, allowing us to better understand and navigate these potentially life-threatening situations.

Personalized Medicine: A Brighter Future for Patients

This study emphasizes the potential of personalized medicine in minimizing the risk of ADRs. By understanding the genetic factors that contribute to these reactions, we can tailor medication regimens to individual patients, reducing the likelihood of adverse events and improving patient safety. This is like finding a hidden oasis in the desert of medical knowledge, offering a source of relief and a path towards a safer and more effective approach to drug therapy.

Dr. Camel's Conclusion

This study underscores the importance of integrating genetics into our understanding of drug therapy. By recognizing the role of HLA alleles in ADRs, we can develop more personalized and effective treatment approaches, minimizing the risk of adverse reactions and improving patient safety. This is like finding a new trail in the desert, opening up new possibilities for a safer and more effective approach to medical care.

Date :
  1. Date Completed 2018-03-23
  2. Date Revised 2019-04-02
Further Info :

Pubmed ID

28315856

DOI: Digital Object Identifier

/j/dmdi.ahead-of-print/dmpt-2016-0025/dmpt-2016-0025.xml

SNS
PICO Info
in preparation
Languages

English

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