Targeting androgen receptor versus targeting androgens to suppress castration resistant prostate cancer.

Author: ChangChawnshang, GuoChangcheng, LiGonghui, LiLei, NiuYuanjie, YehShuyuan, ZhengJunhua

Paper Details 
Original Abstract of the Article :
Prostate cancer (PCa) is the 2nd leading cause of cancer-related death among men in the United States and its progression is tightly associated with the androgen/androgen receptor (AR) signals. Men castrated before puberty (eunuchs) or men with inherited deficiency of type II 5α-reductase (with...See full text at original site
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引用元:
https://doi.org/10.1016/j.canlet.2017.03.022

データ提供:米国国立医学図書館(NLM)

Targeting the Androgen Receptor in Castration Resistant Prostate Cancer: A New Approach

Prostate cancer, a disease that affects millions of men worldwide, is a complex and challenging foe. It's like a relentless desert wind, eroding the body's strength and resilience. Current treatments often rely on androgen deprivation therapy (ADT), which works by reducing the levels of androgens, the male sex hormones that fuel prostate cancer growth. However, this approach, like a temporary oasis, often fails to stop the cancer from spreading, and resistance can develop. This study, like a brilliant desert astronomer, explores a new approach that directly targets the androgen receptor (AR), a key player in prostate cancer growth. The researchers discuss a range of new therapies that aim to block the AR, preventing androgens from binding to it, effectively cutting off the cancer's fuel supply. This approach, like a strategically placed dam, aims to prevent the cancer from advancing.

A New Weapon in the Fight Against Prostate Cancer

The study highlights the potential of directly targeting the androgen receptor in castration-resistant prostate cancer. This approach holds promise, like a newly discovered spring in the desert, for effectively suppressing cancer growth and potentially delaying its progression. The researchers point to several promising therapeutic strategies, including compounds that directly bind to the AR and prevent its activation, as well as silencing the AR using siRNA or non-coding RNAs. This is a significant advancement, like a well-designed irrigation system, allowing for a more targeted and effective approach to fighting this disease.

Fighting Prostate Cancer: A Long and Winding Road

The fight against prostate cancer is a long and arduous journey, like traversing a vast and unforgiving desert. This study highlights a new approach that could potentially improve the odds of survival and slow down the progression of the disease. It's a reminder that even in the face of seemingly insurmountable challenges, there is always hope for new breakthroughs and better treatment options. This study represents a step in the right direction, providing a beacon of hope for patients and researchers alike.

Dr. Camel's Conclusion

This study sheds light on a promising new approach to fighting prostate cancer. By targeting the androgen receptor directly, researchers are looking for a more effective way to suppress cancer growth. It's like a caravan finding a new route through the desert, promising a shorter journey and a better chance of reaching their destination.

Date :
  1. Date Completed 2017-08-25
  2. Date Revised 2018-04-14
Further Info :

Pubmed ID

28323036

DOI: Digital Object Identifier

10.1016/j.canlet.2017.03.022

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SNS
PICO Info
in preparation
Languages

English

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