Targeting the tyrosine kinase signalling pathways for treatment of immune-mediated glomerulonephritis: from bench to bedside and beyond.

Author: MaTerry King-Wing, McAdooStephen P, TamFrederick Wai Keung

Paper Details 
Original Abstract of the Article :
Glomerulonephritis (GN) affects patients of all ages and is an important cause of morbidity and mortality. Non-selective immunosuppressive drugs have been used in immune-mediated GN but often result in systemic side effects and occasionally fatal infective complications. There is increasing evidence...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410974/

データ提供:米国国立医学図書館(NLM)

Targeting Tyrosine Kinase Signaling Pathways in the Fight Against Glomerulonephritis

Glomerulonephritis, an inflammation of the kidneys' filtering units, is a challenging medical condition that can lead to significant health problems. This study takes us on a journey through the complex world of immune-mediated glomerulonephritis, exploring the potential of targeting specific signaling pathways involved in disease development. Researchers focused on tyrosine kinases, key players in cellular communication, investigating their role in the pathogenesis of glomerulonephritis and examining the potential of tyrosine kinase inhibitors as therapeutic agents.

Tyrosine Kinase Inhibitors: A New Frontier in Glomerulonephritis Treatment

This study emphasizes the potential of tyrosine kinase inhibitors as a promising therapeutic approach for immune-mediated glomerulonephritis. Researchers have identified several tyrosine kinases implicated in the disease process, highlighting the need for further research to develop targeted therapies that can selectively block these specific pathways, minimizing side effects and maximizing therapeutic benefit.

Navigating the Path to Kidney Health

Kidney health is vital for overall well-being, and conditions like glomerulonephritis can pose significant challenges. If you experience any symptoms related to your kidneys, it is crucial to consult with a healthcare professional for prompt diagnosis and treatment. The research discussed here underscores the exciting potential of tyrosine kinase inhibitors for treating glomerulonephritis, but more research is needed to translate these promising findings into effective and safe clinical applications.

Dr.Camel's Conclusion

Imagine the kidneys as a majestic desert oasis, diligently filtering and purifying precious resources. Just as a camel needs to maintain a healthy balance of fluids and minerals, individuals with glomerulonephritis require careful attention to their kidney health. This study highlights the potential of targeting specific signaling pathways, like carefully guiding a camel through a complex desert landscape, to potentially restore and maintain healthy kidney function.

Date :
  1. Date Completed 2017-09-28
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

28391340

DOI: Digital Object Identifier

PMC5410974

Related Literature

SNS
PICO Info
in preparation
Languages

English

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