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Fabrication and evaluation of Eudragit<sup>&#174;</sup> polymeric films for transdermal delivery of piroxicam.

Author: ChantasartDoungdaw, JunyaprasertVaraporn Buraphacheep, TeeranachaideekulVeerawat, TocanitchartPreeda, WongrakpanichAmaraporn

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Piroxicam transdermal patches were developed to deliver the drug for extended periods, reducing side effects and improving patient compliance. The patches were made from Eudragit® film formers, a PVC backing membrane, and PEG200 plasticizer. Eudragit® RL100 films exhibited the highest drug release rate and permeation flux across human skin. Increasing drug loading also increased the release rate, highlighting the potential of Eudragit® as a film former for piroxicam delivery.
Paper Details　
Original Abstract of the Article :
The aims of this work were to develop and characterize the prolonged release piroxicam transdermal patch as a prototype to substitute oral formulations, to reduce side effects and improve patient compliance. The patches were composed of film formers (Eudragit<sup>&#174;</sup>) as a matrix backbone, ...See full text at original site
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引用元：
https://doi.org/10.1080/10837450.2017.1319864

データ提供：米国国立医学図書館（NLM）

A Transdermal Delivery System for Piroxicam: A New Approach to Pain Relief

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. This research focuses on the development of a transdermal delivery system for piroxicam, aiming to improve patient compliance and reduce side effects associated with oral administration. Researchers investigated the use of Eudragit® polymers to create a film-based transdermal patch for sustained release of piroxicam. The study found that Eudragit® RL100 films exhibited the highest drug release rate and permeation flux across human epidermal membrane, suggesting its potential for effective transdermal delivery of piroxicam.

Transdermal Piroxicam: A More Convenient and Effective Option

The development of a transdermal delivery system for piroxicam offers a more convenient and potentially more effective way to deliver this medication. By bypassing the gastrointestinal tract, this approach could minimize the risk of gastrointestinal side effects commonly associated with oral NSAIDs. The sustained release aspect of the transdermal patch could also provide more consistent drug levels in the body, leading to improved pain management.

A Step Towards More Effective Pain Relief: Transdermal Delivery

This research opens up new possibilities for transdermal delivery of NSAIDs, offering a more convenient and potentially safer alternative to oral administration. Transdermal delivery systems could improve patient compliance and reduce the incidence of gastrointestinal side effects. This approach could revolutionize pain management, offering patients a more comfortable and effective way to address their pain and inflammation.

Dr.Camel's Conclusion

Just as a camel can traverse vast deserts with its ability to store water, this research aims to create a way to deliver pain relief directly through the skin. This transdermal delivery system has the potential to revolutionize pain management, offering a more convenient and potentially safer option for patients. It's a step towards a more comfortable and effective way to navigate the desert of pain and inflammation.

Date :
  1. Date Completed 2018-11-12
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28406344

DOI: Digital Object Identifier

10.1080/10837450.2017.1319864

Related Literature

Article Analysis
・Side Effects of piroxicam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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