Paper Details 
Original Abstract of the Article :
Older patients can be especially susceptible to antipsychotic-induced side effects, and the pharmacodynamic mechanism underlying this phenomenon remains unclear. We hypothesized that age-related epigenetic alterations lead to decreased expression and functionality of the dopamine D2 receptor (D2R), ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://pubmed.ncbi.nlm.nih.gov/28421257

データ提供:米国国立医学図書館(NLM)

Age and Antipsychotics: Navigating the Shifting Sands of Epigenetics

This study delves into the complex relationship between age and the effectiveness of antipsychotic medications. Imagine a desert landscape, where the harsh conditions and shifting sands can affect the journey of travelers. This study, like a meticulous explorer, investigates the epigenetic changes that occur with age, potentially influencing the efficacy of antipsychotics. The researchers, like skilled desert guides, explore the potential role of epigenetic alterations in reducing the effectiveness of antipsychotics in older patients, leading to a higher risk of side effects.

Unveiling the Secrets of Age and Antipsychotics: A Journey Through Epigenetic Terrain

The study unveils the potential influence of age-related epigenetic alterations on the effectiveness of antipsychotics, like uncovering hidden secrets in a vast desert landscape. The researchers, like skilled cartographers, map out the intricate relationship between epigenetic changes and the functionality of dopamine receptors. This research, like a compass guiding explorers through unfamiliar terrain, sheds light on the complex interplay between age, epigenetics, and the effectiveness of antipsychotics.

A Deeper Understanding of Antipsychotic Therapy: Navigating the Shifting Sands of Age

This research, like a guide to the desert's diverse landscape, offers a deeper understanding of the factors influencing the effectiveness of antipsychotics in older patients. The researchers, like skilled desert navigators, emphasize the importance of considering age-related epigenetic changes when prescribing these medications. This research, like a well-placed oasis in the desert, provides valuable insights for optimizing antipsychotic therapy, potentially improving treatment outcomes for older patients.

Dr.Camel's Conclusion

The study reveals the intricate relationship between age, epigenetics, and the effectiveness of antipsychotics. By uncovering the potential role of epigenetic alterations, the research provides a deeper understanding of the challenges faced by older patients taking antipsychotic medications. This research, like a journey through the vast and complex desert of epigenetics, offers valuable insights for improving antipsychotic therapy in older patients.

Date :
  1. Date Completed 2018-03-26
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

28421257

DOI: Digital Object Identifier

NIHMS869318

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.