Association of Aflatoxin and Gallbladder Cancer.

Author: AndersenJesper B, DeanMichael, EgnerPatricia, FerreccioCatterina, GaoYu-Tang, GroopmanJohn, HildesheimAllan, HsingAnn W, JonesKristine, KoshiolJill, LuoWen, MalaskyMichael, NepalChirag, RashidAsif, ShenMing-Chang, Van DykeAlison L, WangBingsheng, ZhuBin

Paper Details 
Original Abstract of the Article :
BACKGROUND & AIMS: Aflatoxin, which causes hepatocellular carcinoma, may also cause gallbladder cancer. We investigated whether patients with gallbladder cancer have higher exposure to aflatoxin than patients with gallstones. METHODS: We measured aflatoxin B RESULTS: The AFB CONCLUSIONS: In a cas...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/28428144

データ提供:米国国立医学図書館(NLM)

Aflatoxin and Gallbladder Cancer: A Potential Link

Gallbladder cancer is a serious disease that can be difficult to diagnose and treat. Researchers in the field of oncology are constantly searching for the causes and risk factors associated with gallbladder cancer, aiming to improve prevention and early detection strategies. This case-control study investigates the potential association between aflatoxin exposure and gallbladder cancer, exploring a possible link between environmental toxins and this disease.

Aflatoxin: A Potential Risk Factor for Gallbladder Cancer?

This case-control study found a significant association between aflatoxin exposure and gallbladder cancer. The researchers found that patients with gallbladder cancer had higher levels of aflatoxin B1 in their plasma compared to those with gallstones without cancer. This finding suggests that aflatoxin exposure may be a potential risk factor for gallbladder cancer, although further research is needed to confirm this association and understand the underlying mechanisms. The study also found that patients with lower levels of aflatoxin M1, a metabolite of aflatoxin B1, were more likely to have gallbladder cancer. This finding suggests that aflatoxin metabolism may be important in determining individual susceptibility to gallbladder cancer.

Implications for Gallbladder Cancer Prevention

This study's findings have important implications for gallbladder cancer prevention, highlighting the potential importance of reducing aflatoxin exposure. The study suggests that minimizing exposure to aflatoxin-contaminated foods, particularly in regions with high aflatoxin levels, may help to reduce the risk of gallbladder cancer. Further research is needed to understand the specific mechanisms by which aflatoxin may contribute to gallbladder cancer and develop targeted interventions for prevention.

Dr.Camel's Conclusion

This case-control study is like a camel caravan crossing a desert landscape, uncovering the potential link between aflatoxin exposure and gallbladder cancer. The findings suggest that reducing aflatoxin exposure may be a valuable strategy for preventing this serious disease, urging us to pay attention to environmental toxins and their potential impact on our health.

Date :
  1. Date Completed 2017-08-31
  2. Date Revised 2019-10-08
Further Info :

Pubmed ID

28428144

DOI: Digital Object Identifier

NIHMS869421

Related Literature

SNS
PICO Info
in preparation
Languages

English

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