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Lipophilicity estimation of statins as a decisive physicochemical parameter for their hepato-selectivity using reversed-phase thin layer chromatography.

Author: Abdel-RahmanHamdy M, AtiaNoha N, RagehAzza H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Lipophilicity plays a crucial role in determining the hepato-selectivity and associated side effects of statins. This study examined the use of RP-TLC for estimating the lipophilicity of six statins.
Paper Details　
Original Abstract of the Article :
Lipophilicity plays a crucial role in determining the hepato-selectivity and hence, the biological activity and the associated side effects of statins. Herein, the employment of RP-TLC for estimation of lipophilicity of six statins namely; atorvastatin, simvastatin, pravastatin, lovastatin, rosuvast...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2017.04.037

データ提供：米国国立医学図書館（NLM）

Statins and Lipophilicity: A Balancing Act in the Desert

Statins, medications commonly used to lower cholesterol, are a vital tool in the fight against heart disease. However, their lipophilicity (fat-loving tendency) plays a crucial role in their hepato-selectivity (how they distribute to the liver), influencing both their effectiveness and potential side effects. This study utilized reversed-phase thin-layer chromatography (RP-TLC) to assess the lipophilicity of six statins, aiming to understand their potential for liver-related side effects. The researchers found a strong correlation between lipophilicity and the distribution of these statins, suggesting that lipophilicity could serve as a valuable predictor of their hepato-selectivity.

Navigating Lipophilicity: A Path to Safer Statins

This study demonstrates the importance of considering lipophilicity when evaluating the safety and effectiveness of statins. The researchers' findings suggest that RP-TLC could be a useful tool for predicting the potential for liver-related side effects associated with statins. This information can help guide the development of safer and more effective statins for patients.

Living with Statins: Balancing Benefits and Risks

Statins are an essential part of managing cholesterol levels and preventing heart disease. However, it's crucial to be aware of potential side effects and discuss concerns with your doctor. Understanding the lipophilicity of statins and their potential for hepato-selectivity can help patients and healthcare providers make informed decisions about medication choices and monitoring.

Dr.Camel's Conclusion

This research highlights the importance of lipophilicity as a crucial factor in determining the effectiveness and safety of statins. By understanding the relationship between lipophilicity and hepato-selectivity, we can create more targeted and safer statin therapies for patients, ensuring a smoother journey through the desert of heart health.

Date :
  1. Date Completed 2018-01-19
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28477451

DOI: Digital Object Identifier

10.1016/j.jpba.2017.04.037

SNS
PICO Info
in preparation
Languages

English

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