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S-Adenosylmethionine-mediated apoptosis is potentiated by autophagy inhibition induced by chloroquine in human breast cancer cells.

Author: CacciapuotiGiovanna, CaragliaMichele, CaveDonatella Delle, DesiderioVincenzo, IlissoConcetta P, MeleLuigi, MoscaLaura, PorcelliMarina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

S-adenosyl-L-methionine (AdoMet) inhibits breast cancer cell proliferation by inducing both autophagy and apoptosis. AdoMet significantly increased levels of autophagy markers beclin-1 and LC3B-II, as well as the pro-apoptotic Bax/Bcl-2 ratio, leading to PARP and caspase cleavage. Moreover, AdoMet increased the percentage of cells in the G<sub>2</sub>/M phase of the cell cycle, downregulating cyclin B and cyclin E while upregulating p53, p27, and p21. Blocking autophagy with chloroquine synergistically enhanced both growth inhibition and apoptosis, further supporting the role of autophagy as an escape mechanism from AdoMet-induced apoptosis. This finding suggests AdoMet, in combination with autophagy inhibitors, may be a promising therapeutic strategy for breast cancer.
Paper Details　
Original Abstract of the Article :
The naturally occurring sulfonium compound S-adenosyl-L-methionine (AdoMet) is an ubiquitous sulfur-nucleoside that represents the main methyl donor in numerous methylation reactions. In recent years, it has been shown that AdoMet possesses antiproliferative properties in various cancer cells, but t...See full text at original site
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引用元：
https://doi.org/10.1002/jcp.26015

データ提供：米国国立医学図書館（NLM）

AdoMet and Chloroquine: A New Alliance in the Desert of Breast Cancer

Breast cancer, a prevalent and often aggressive disease, requires ongoing research into effective treatment options. Imagine breast cancer as a vast desert, with tumor cells spreading like an encroaching sandstorm. This research investigates the potential of AdoMet, a naturally occurring sulfur-nucleoside, as a novel anti-cancer agent, exploring its synergistic effects with the autophagy inhibitor chloroquine.

AdoMet and Chloroquine: A Powerful Partnership Against Breast Cancer

The research reveals that AdoMet, like a resilient desert plant, exhibits anti-proliferative properties in breast cancer cells. Furthermore, the authors demonstrate that combining AdoMet with the autophagy inhibitor chloroquine, like forging an alliance between two desert warriors, significantly enhances the anti-cancer effects. This synergistic combination effectively inhibits tumor growth and promotes apoptosis, offering a promising new approach to treating breast cancer.

Navigating the Landscape of Breast Cancer Treatment

This research opens up new avenues for exploring the potential of AdoMet and chloroquine as a combination therapy for breast cancer. It's like discovering a new oasis in the desert of cancer treatment, offering a potentially more effective and targeted approach. The authors encourage further investigation into the clinical efficacy and safety of this combination therapy, paving the way for future advancements in breast cancer treatment.

Dr.Camel's Conclusion

This research explores the potential of AdoMet and chloroquine as a formidable alliance against breast cancer. Like a team of resourceful desert travelers, these agents work together to combat tumor growth, offering a new and potentially effective weapon in the fight against this challenging disease. Further research into this promising combination therapy holds the key to unlocking new possibilities for breast cancer treatment.

Date :
  1. Date Completed 2017-11-13
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

28518408

DOI: Digital Object Identifier

10.1002/jcp.26015

SNS
PICO Info
in preparation
Languages

English

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